5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

Base Information

Chemical Name:5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole
CAS No.:346426-76-4
Molecular Formula:C₂₂H₂₅N₂O₅P
Molecular Weight:428.425
Hs Code.:

Synonyms:5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

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Chemical Property of 5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

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Technology Process of 5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

There total 6 articles about 5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 346426-68-4
C₂₂H₂₆ClN₂O₅P

: 346426-76-4
5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

Guidance literature:: With PS-DIEA resin; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ja015632f

Reference yield:

: 346426-66-2
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid

: 346426-76-4
5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / CH₂Cl₂ / 10 h / 20 °C

2: Ph₃PCl₂; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

3: PS-DIEA resin / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; PS-DIEA resin; chloro(triphenyl)phosphonium chloride; In dichloromethane;
DOI:10.1021/ja015632f

Reference yield:

: 346426-62-8
(benzyloxycarbonylamino-cyclohexyl-methyl)phosphinic acid 4-nitrobenzyl ester

: 346426-76-4
5-benzyloxy-3-cyclohexyl-2-(4-nitro-benzyloxy)-2,3-dihydro-[1,4,2]oxazaphosphole

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃PCl₂; pyridine / CH₂Cl₂ / 0.5 h / 20 °C

2: PS-DIEA resin / CH₂Cl₂ / 0.5 h / 20 °C

With pyridine; PS-DIEA resin; chloro(triphenyl)phosphonium chloride; In dichloromethane;
DOI:10.1021/ja015632f