4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

Base Information

Chemical Name:4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile
CAS No.:959690-45-0
Molecular Formula:C₂₀H₁₆F₃N₃O₃
Molecular Weight:403.361
Hs Code.:

Synonyms:4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

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Chemical Property of 4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

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Technology Process of 4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

There total 6 articles about 4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 627531-79-7
4-cyano-2-methyl-3-trifluoromethylphenyl isocyanate

: 959694-48-5
methyl 2-(4-hydroxyphenyl)-2-(methylamino)propionate

: 959690-45-0
4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

Guidance literature:: In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm300249m

Reference yield:

: 938-96-5
2-(4-Hydroxy-phenyl)-propionic acid

: 959690-45-0
4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3.5 h / 0 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran / 0 °C / Inert atmosphere

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 7 h / Inert atmosphere; Reflux

4: tetrahydrofuran; ethanol / 0.5 h / 20 °C / Inert atmosphere

5: tetrahydrofuran / 20 °C / Inert atmosphere

With N-Bromosuccinimide; thionyl chloride; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm300249m

Reference yield:

: 65784-33-0
methyl 2-(4-hydroxyphenyl)propanoate

: 959690-45-0
4-[3,4-dimethyl-2,5-dioxo-4-(4-hydroxyphenyl)imidazolidin-1-yl]-3-methyl-2-trifluoromethylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / tetrahydrofuran / 0 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 7 h / Inert atmosphere; Reflux

3: tetrahydrofuran; ethanol / 0.5 h / 20 °C / Inert atmosphere

4: tetrahydrofuran / 20 °C / Inert atmosphere

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrahydrofuran; tetrachloromethane; ethanol;
DOI:10.1021/jm300249m