(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

Base Information

Chemical Name:(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine
CAS No.:204443-45-8
Molecular Formula:C₁₅H₂₀O₃
Molecular Weight:248.322
Hs Code.:

Synonyms:(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

Chemical Property:

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Technology Process of (S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

There total 3 articles about (S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 204443-43-6
[(S)-2-(1-Methoxy-allyloxy)-hex-5-enyloxymethyl]-benzene

: 204443-45-8
(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 4h; Ambient temperature;
DOI:10.1055/s-1998-1598

Reference yield:

: 2930-05-4,14618-80-5,89616-40-0,16495-13-9
(S)-benzyl glycidyl ether

: 204443-45-8
(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

Guidance literature:: Multi-step reaction with 3 steps

1: 48 percent / Me₂S, CuI / tetrahydrofuran / 2 h / 0 °C

2: 89 percent / Et₃N / Pd(OAc)2, Ph₂P(CH₂)3PPh₂ / acetonitrile / 3 h / 80 °C

3: 69 percent / Cl₂(PCy₃)2RuCHPh / CH₂Cl₂ / 4 h / Ambient temperature

With copper(l) iodide; dimethylsulfide; triethylamine; palladium diacetate; Grubbs catalyst first generation; 1,3-bis-(diphenylphosphino)propane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1055/s-1998-1598

Reference yield:

: 155418-40-9
(2S)-1-(benzyloxy)hex-5-en-2-ol

: 204443-45-8
(S)-2-Benzyloxymethyl-7-methoxy-2,3,4,7-tetrahydro-oxepine

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / Et₃N / Pd(OAc)2, Ph₂P(CH₂)3PPh₂ / acetonitrile / 3 h / 80 °C

2: 69 percent / Cl₂(PCy₃)2RuCHPh / CH₂Cl₂ / 4 h / Ambient temperature

With triethylamine; palladium diacetate; Grubbs catalyst first generation; 1,3-bis-(diphenylphosphino)propane; In dichloromethane; acetonitrile;
DOI:10.1055/s-1998-1598