S-(4-bromophenyl)-S-methyl-sulfoximine

Base Information

• Chemical Name: S-(4-bromophenyl)-S-methyl-sulfoximine
• CAS No.: 848991-21-9
• Molecular Formula: C₇H₈BrNOS
• Molecular Weight: 234.117
• Mol file: 848991-21-9.mol

Synonyms:S-(4-bromophenyl)-S-methyl-sulfoximine

Chemical Property of S-(4-bromophenyl)-S-methyl-sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of S-(4-bromophenyl)-S-methyl-sulfoximine

There total 6 articles about S-(4-bromophenyl)-S-methyl-sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(S)-methyl p-bromophenyl sulfoxide (145166-15-0) → S-(4-bromophenyl)-S-methyl-sulfoximine (848991-21-9)

Guidance literature:

With perchloric acid; mesitiylenesulfonyl acetoxyhydroxamate; In 1,4-dioxane; dichloromethane; water; at 20 ℃; for 48h;

DOI:10.1021/jo047940c

Reference yield: 41.0%

2-(dimethyl(oxo)-λ6-sulfaneylidene)-1-phenylethan-1-one (20718-17-6) + 1-bromo-4-(S-methylsulfonimidoyl)benzene (145026-07-9) → (R)-(4-bromophenyl)(imino)(methyl)-λ6-sulfanone (848991-21-9) + (S)-6-bromo-1-methyl-3-phenyl-1λ4-benzo[e][1,2]thiazine 1-oxide + (R)-6-bromo-1-methyl-3-phenyl-1λ4-benzo[e][1,2]thiazine 1-oxide

Guidance literature:

With silver hexafluoroantimonate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; (S)-2'-(dicyclohexylcarbamoyl)-[1,1'-binaphthalene]-2-carboxylic acid; In Trichloroethylene; tert-butyl alcohol; at 50 ℃; for 12h; enantioselective reaction; Resolution of racemate; Inert atmosphere; Schlenk technique;

DOI:10.1021/jacs.1c03111

Reference yield:

4-bromobenzenesulfonyl chloride (98-58-8) → S-(4-bromophenyl)-S-methyl-sulfoximine (848991-21-9)

Guidance literature:

Multi-step reaction with 3 steps

1: P(OMe)3; Et₃N / CH₂Cl₂

2: toluene / 5 °C

3: 86 percent / O-(mesitylsulfonyl)acetohydroxamate; perchloric acid / dioxane; H₂O; CH₂Cl₂ / 48 h / 20 °C

With perchloric acid; triethylamine; mesitiylenesulfonyl acetoxyhydroxamate; phosphorous acid trimethyl ester; In 1,4-dioxane; dichloromethane; water; toluene; 2: Grignard reaction;

DOI:10.1021/jo047940c

upstream raw materials:

(S)-methyl p-bromophenyl sulfoxide

4-bromobenzenesulfonyl chloride

(1R,2S,5R)-menthyl (S)-p-bromobenzene sulfinate

2-nitrocinnamic aldehyde

Downstream raw materials:

C₂₁H₂₅BrN₂O₄S

(R)-N-(2-nitrophenyl)-S-(4-bromophenyl)-S-methylsulfoximine