145026-07-9

Basic information

• Product Name: 1-Bromo-4-(S-Methylsulfonimidoyl)Benzene
• Synonyms: 1-Bromo-4-(S-Methylsulfonimidoyl)Benzene;1-Bromo-4-(S-Methylsulfonimidoyl)Benzene(WXC00640)
• CAS NO: 145026-07-9
• Molecular Formula: C₇H₈BrNOS
• Molecular Weight: 234.11352
• Mol File: 145026-07-9.mol
• Article Data: 23

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Bromo-4-(S-Methylsulfonimidoyl)Benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-4-(S-Methylsulfonimidoyl)Benzene(145026-07-9)
• EPA Substance Registry System: 1-Bromo-4-(S-Methylsulfonimidoyl)Benzene(145026-07-9)

Safety Data

• Hazardous Substances Data: 145026-07-9(Hazardous Substances Data)

Usage

Explanation

Different sources of media describe the Explanation of 145026-07-9 differently. You can refer to the following data:
1. The molecular formula represents the total number of atoms of each element present in the compound.
2. The compound is derived from benzene, with modifications involving the attachment of a bromine atom and an S-methylsulfonimidoyl group.
3. These groups are responsible for the compound's reactivity and its use in various chemical reactions.
4. The compound is used as a building block for creating biologically active molecules and functional materials.
5. Due to its unique structure and reactivity, the compound can be employed in the synthesis of a wide range of molecules with potential applications.
6. The compound serves as an important intermediate in the manufacturing process of various chemical products, including pharmaceuticals, agrochemicals, and fine chemicals.
7. The specific arrangement of these functional groups on the benzene ring contributes to the compound's unique properties and reactivity.

Molecular structure

Benzene derivative with a bromine atom and an S-methylsulfonimidoyl group

Functional groups

Bromine atom, S-methylsulfonimidoyl group

Application

Organic synthesis and pharmaceutical research

Versatility

Can be used to synthesize various biologically active molecules

Intermediate in production

Pharmaceuticals, agrochemicals, and fine chemicals

Unique structure

Contains a bromine atom and an S-methylsulfonimidoyl group attached to the fourth carbon of the benzene ring

Upstream product

• 106-53-6 para-bromobenzenethiol 
• 104-95-0 (4-bromophenyl)thioanisole 
• 934-71-4 1-bromo-4-(methylsulfinyl)benzene 

Downstream Products

• 1584154-60-8 (benzhydrylimino)(4-bromophenyl)(methyl)-λ⁶-sulfanone 
• 1572535-62-6 N-((4-bromophenyl)(methyl)(oxo)-λ6-sulfanylidene)benzamide 
• 1572928-15-4 N-methyl-S-(4-bromophenyl)-S-methylsulfoximine 
• 1638133-97-7 N-(11-undecenyl)-S-(4-bromophenyl)-S-methylsulfoximine 
• 1572927-56-0 5-(((3S)-4-(4-(S)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine 
• 1572927-57-1 5-(((3S)-4-(4-(R)-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinamine 
• 1572928-18-7 tert-butyl (5-(((3S)-4-(4-(N,S-dimethylsulfonimidoyl)phenyl)-3-(1-propyn-1-yl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate 

Relevant articles and documents

Electrochemical Oxidative Syntheses of NH-Sulfoximines, NH-Sulfonimidamides and Dibenzothiazines via Anodically Generated Hypervalent Iodine Intermediates

Herein, we report a general method for the synthesis of NH-sulfoximines and NH-sulfonimidamides through direct electrochemical oxidative catalysis involving an iodoarene(I)/iodoarene(III) redox couple. In addition, dibenzothiazines can be synthesized from [1,1′-biaryl]-2-sulfides under standard conditions. Notably, only a catalytic amount of iodoarene is required for the generation in situ of an active hypervalent iodine catalyst, which avoids the need for an excess of a hypervalent iodine reagent relative to conventional approaches. Moreover, this protocol features broad substrate scope and wide functional group tolerance, delivering the target compounds with good-to-excellent yields even for a scale of more than 10 g.

Synthesis of NH-Sulfoximines by Using Recyclable Hypervalent Iodine(III) Reagents under Aqueous Micellar Conditions

The synthesis of NH-sulfoximines from sulfides has been first developed under mild conditions in an aqueous solution with surfactant TPGS-750-M as the catalyst at room temperature. In this newly developed process, a simple and convenient recycling strategy to regenerate the indispensable hypervalent iodine(III) is used. The resulting 1,2,3-trifluoro-5-iodobezene can be recovered almost quantitively from the mixture by liquid–liquid extraction and then oxidized to give the corresponding iodine(III) species. This optimized procedure is compatible with a broad range of functional groups and can be easily performed on a gram scale, providing a green protocol for the synthesis of sulfoximines.

NOVEL BIPHENYLSULFOXIMINES AS ALLOSTERIC MODULATORS OF THE DOPAMINE D1 RECEPTOR

The present invention relates to new biphenylsulfoximine compounds and, in particular, to their activity as positive allosteric modulators of the dopamine D1 receptor and to their use for the treatment of pathological states for which a stimulator of this receptor activity is indicated. The invention further relates to pharmaceutical compositions containing them and to a process for the preparation of such compounds.