2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

Base Information

• Chemical Name: 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid
• CAS No.: 184427-38-1
• Molecular Formula: C₁₂H₁₁BrN₂O₄
• Molecular Weight: 327.134

Synonyms:2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

Chemical Property of 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

Chemical Property:

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Technology Process of 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

There total 8 articles about 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea (184427-37-0) → 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid (184427-38-1)

Guidance literature:

With hydrogenchloride; for 10h; Heating;

Reference yield:

(S)-2-amino-2-(4-bromophenyl)-propionic acid ethyl ester (184427-34-7) → 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid (184427-38-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / N-ethylmorpholine / dimethylformamide / 5 h / 0 - 22 °C

2: 78 percent / 6 N aq. HCl / 0.5 h / Heating

With N-ethylmorpholine;; hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm001068s

Reference yield:

(R,S)-2-amino-2-(4-bromophenyl)-propionic acid ethyl ester (184427-33-6) → 2-((S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid (184427-38-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 28 percent / via salt with R-mandelic acid

2: 99 percent / N-ethylmorpholine / dimethylformamide / 5 h / 0 - 22 °C

3: 78 percent / 6 N aq. HCl / 0.5 h / Heating

With N-ethylmorpholine;; hydrogenchloride; In N,N-dimethyl-formamide;

DOI:10.1021/jm001068s

upstream raw materials:

[(S)-4-(4-Bromo-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-acetic acid ethyl ester

N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

(R,S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidine

(R,S)-2-amino-2-(4-bromophenyl)-propionic acid

Downstream raw materials:

2-((S)-4-(4-Cyanophenyl)-4-methyl-2,5-dioxoimidazolidin-1-yl)acetic acid

3-{2-[4-(S)-(4-aminoiminomethyl-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]acetylamino}-3-(R)-phenylpropionic acid ethyl ester

(S)-3-{2-[(S)-4-(4-Carbamimidoyl-phenyl)-4-methyl-2,5-dioxo-imidazolidin-1-yl]-acetylamino}-3-phenyl-propionic acid ethyl ester

(S)-3-(2-{(S)-4-[4-(N-Hydroxycarbamimidoyl)-phenyl]-4-methyl-2,5-dioxo-imidazolidin-1-yl}-acetylamino)-3-phenyl-propionic acid ethyl ester

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