N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

Base Information

Chemical Name:N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea
CAS No.:184427-37-0
Molecular Formula:C₁₆H₂₁BrN₂O₅
Molecular Weight:401.257
Hs Code.:

Synonyms:N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

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Chemical Property of N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

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Technology Process of N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

There total 5 articles about N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 184427-34-7
(S)-2-amino-2-(4-bromophenyl)-propionic acid ethyl ester

: 2949-22-6
Glycine ethyl ester isocyanate

: 184427-37-0
N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

Guidance literature:: In dichloromethane; at 0 ℃; for 2h;

Reference yield:

: 6320-50-9
(R,S)-4-(4-bromophenyl)-4-methyl-2,5-dioxoimidazolidine

: 184427-37-0
N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / 3 N aq. NaOH / 1 h / 145 °C / 7500.75 Torr

2: 68 percent / 18 h / Heating

3: 28 percent / via salt with R-mandelic acid

4: 99 percent / N-ethylmorpholine / dimethylformamide / 5 h / 0 - 22 °C

With N-ethylmorpholine;; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm001068s

Reference yield:

: 72408-57-2
(R,S)-2-amino-2-(4-bromophenyl)-propionic acid

: 184427-37-0
N-((S)-1-(4-bromophenyl)-1-(ethoxycarbonyl)ethyl)-N'-(ethoxy-carbonylmethyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / 18 h / Heating

2: 28 percent / via salt with R-mandelic acid

3: 99 percent / N-ethylmorpholine / dimethylformamide / 5 h / 0 - 22 °C

With N-ethylmorpholine;; In N,N-dimethyl-formamide;
DOI:10.1021/jm001068s