2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

Base Information

Chemical Name:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid
CAS No.:237394-53-5
Molecular Formula:C₃₆H₅₀NO₆P
Molecular Weight:623.77
Hs Code.:

Synonyms:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

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Chemical Property of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

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Technology Process of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

There total 5 articles about 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 237394-40-0
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

: 237394-53-5
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

Guidance literature:: With sodium hydroxide; In methanol; for 18h;
DOI:10.1021/jm9900164

Reference yield:

: 768-90-1
1-Adamantyl bromide

: 237394-53-5
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / silver oxide / CHCl₃ / 0.5 h / Heating

2: 78 percent / 4N aq. NaOH / methanol / 18 h

With sodium hydroxide; silver(l) oxide; In methanol; chloroform;
DOI:10.1021/jm9900164

Reference yield:

: 111-25-1
1-bromo-hexane

: 237394-53-5
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, I₂, 2.) CuI / 1.) diethyl ether, reflux, 1 h, 2.) diethyl ether, THF, RT, 30 min

2: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

3: 96 percent / silver oxide / CHCl₃ / 0.5 h / Heating

4: 78 percent / 4N aq. NaOH / methanol / 18 h

With sodium hydroxide; copper(l) iodide; iodine; magnesium; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In methanol; chloroform;
DOI:10.1021/jm9900164