2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

Base Information

Chemical Name:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester
CAS No.:237394-40-0
Molecular Formula:C₃₈H₅₄NO₆P
Molecular Weight:651.824
Hs Code.:

Synonyms:2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

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Chemical Property of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

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Technology Process of 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

There total 4 articles about 2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 768-90-1
1-Adamantyl bromide

: 237394-26-2
2-[(1-benzyloxycarbonylamino-2-phenyl-ethyl)-hydroxy-phosphinoylmethyl]-nonanoic acid ethyl ester

: 237394-40-0
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

Guidance literature:: With silver(l) oxide; In chloroform; for 0.5h; Heating;
DOI:10.1021/jm9900164

Reference yield:

: 81143-90-0
ethyl 2-heptyl-2-propenoate

: 237394-40-0
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

2: 96 percent / silver oxide / CHCl₃ / 0.5 h / Heating

With 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In chloroform;
DOI:10.1021/jm9900164

Reference yield:

: 111-25-1
1-bromo-hexane

: 237394-40-0
2-[(adamantan-1-yloxy)-(1-benzyloxycarbonylamino-2-phenyl-ethyl)-phosphinoylmethyl]-nonanoic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Mg, I₂, 2.) CuI / 1.) diethyl ether, reflux, 1 h, 2.) diethyl ether, THF, RT, 30 min

2: 1.) hexamethyldisilazane / 1.) 110 deg C, 1 h, 2.) 110 deg C, 3 h

3: 96 percent / silver oxide / CHCl₃ / 0.5 h / Heating

With copper(l) iodide; iodine; magnesium; 1,1,1,3,3,3-hexamethyl-disilazane; silver(l) oxide; In chloroform;
DOI:10.1021/jm9900164