4-P-AMINOPHENYL-1-BOC-PIPERIDINE

Base Information

• Chemical Name: 4-P-AMINOPHENYL-1-BOC-PIPERIDINE
• CAS No.: 170011-57-1
• Molecular Formula: C16H24N2O2
• Molecular Weight: 276.379
• Hs Code.: 2933399090
• Mol file: 170011-57-1.mol

Synonyms:tert-Butyl 4-(4-aminophenyl)-1-piperidinecarboxylate;

Chemical Property of 4-P-AMINOPHENYL-1-BOC-PIPERIDINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 119 °C
• Refractive Index: 1.551
• Boiling Point: 412.737 °C at 760 mmHg
• PKA: 4.97±0.10(Predicted)
• Flash Point: 203.417 °C
• PSA: 55.56000
• Density: 1.1 g/cm³
• LogP: 3.90240
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-4-(4-aminophenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-P-AMINOPHENYL-1-BOC-PIPERIDINE

There total 25 articles about 4-P-AMINOPHENYL-1-BOC-PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

para-nitrophenyl bromide (586-78-7) + tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate (375853-82-0,286961-14-6) → tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate (170011-57-1)

Guidance literature:

para-nitrophenyl bromide; tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; With potassium phosphate; chloro(2-dicyclohexylphosphino-2’,4’,6’-triisopropyl-1,1‘-biphenyl)[2-(2’-amino-1,1‘-biphenyl’)]palladium(II); palladium 10% on activated carbon; In 1,4-dioxane; water; at 80 ℃; for 4h; Sealed tube; Inert atmosphere;

With ammonium bicarbonate; In methanol; at 18 ℃; for 16h;

DOI:10.1039/c7cc08670a

Reference yield: 93.9%

4-(4-nitrophenyl)piperidine-1-carboxylic acid tert-butyl ester (170011-56-0) → tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate (170011-57-1)

Guidance literature:

With tin(ll) chloride; In water; N,N-dimethyl-formamide; at 20 ℃; for 3h; Cooling with ice;

Reference yield: 84.0%

4-(4-benzyloxycarbonylaminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (873454-39-8) → tert-butyl 4-(4-aminophenyl)piperidin-1-carboxylate (170011-57-1)

Guidance literature:

With hydrogen; palladium over charcoal; In methanol; at 20 ℃; for 1h;

upstream raw materials:

di-tert-butyl dicarbonate

4-(4-nitrophenyl)piperidine-1-carboxylic acid tert-butyl ester

4-(4-aminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

4-(4-benzyloxycarbonylaminophenyl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

tert-butyl 4-(4-(3-(2-(1-(2-chlorophenyl)-3-methyl-1H-pyrazol-5-yloxy)phenyl)ureido)phenyl)piperidine-1-carboxylate

4-(4-amino-3-bromophenyl)piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-(4-amino-3-iodophenyl)piperidine-1-carboxylate

2-[4-(1-tert-butoxycarbonyl-piperidin-4-yl)-phenylamino]-8-(4-ethyl-phenyl)-5-oxo-5,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid ethyl ester

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