5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• CAS No.: 939431-45-5
• Molecular Formula: C₄₈H₅₉N₄O₁₅P
• Molecular Weight: 962.988
• Mol file: 939431-45-5.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 4 articles about 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

L-5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine (880138-72-7) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (939431-45-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1002/jhet.5570440208

Reference yield:

L-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolanoic acid] (880138-63-6) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (939431-45-5)

Guidance literature:

Multi-step reaction with 3 steps

1: TBAF

With tetrabutyl ammonium fluoride;

DOI:10.1081/NCN-200061895

Reference yield:

3',5'-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine (69304-38-7) → 5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite (939431-45-5)

Guidance literature:

Multi-step reaction with 4 steps

1: H⁺

2: TBAF

With tetrabutyl ammonium fluoride; hydrogen cation;

DOI:10.1081/NCN-200061895

upstream raw materials:

L-5'-O-(4,4'-dimethoxytrityl)-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

L-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolanoic acid]

L-2'-O-[4,5-di(ethoxycarbonyl)-1,3-dioxolan-2-yl]uridine

Downstream raw materials:

C₅₄H₆₀N₅O₂₂P