benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate

Base Information

• Chemical Name: benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate
• CAS No.: 138108-37-9
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.415
• Mol file: 138108-37-9.mol

Synonyms:benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate

Chemical Property of benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate

There total 7 articles about benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) + benzyl 3-aminopropionate (14529-00-1) → benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate (138108-37-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;

DOI:10.1016/j.bmcl.2008.07.082

Reference yield: 74.0%

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) + β-alanine benzyl ester p-toluenesulfonate (27019-47-2) → benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate (138108-37-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2008.09.013

Reference yield:

3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → benzyl 3-(3-(tert-butoxycarbonylamino)propanamido)propanoate (138108-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / tetrahydrofuran / 0.25 h / -15 °C

2: 11.4 g / tetrahydrofuran / 72 h / 20 °C

With TEA; In tetrahydrofuran;

DOI:10.1002/chem.200500249

upstream raw materials:

3-(tert-butyloxycarbonylamino)propionic acid

benzyl 3-aminopropionate

β-alanine benzyl ester p-toluenesulfonate

3-(benzyloxy)-3-oxopropan-1-aminium chloride

Downstream raw materials:

N-[N-[p-[N-(benzyloxycarbonyl)amidino]benzoyl]-β-alanyl]-β-alanine benzylester

3-[3-(4-Carbamimidoyl-benzoylamino)-propionylamino]-propionic acid benzyl ester