2-CHLORO-5-METHOXYBENZIMIDAZOLE

Base Information

• Chemical Name: 2-CHLORO-5-METHOXYBENZIMIDAZOLE
• CAS No.: 15965-54-5
• Molecular Formula: C8H7ClN2O
• Molecular Weight: 182.609
• Hs Code.: 2933990090
• Mol file: 15965-54-5.mol

Synonyms:1H-Benzimidazole,2-chloro-5-methoxy- (9CI);Benzimidazole, 2-chloro-5-methoxy- (8CI);2-Chloro-5-methoxy-1H-benzimidazole;2-Chloro-5-methoxybenzimidazole;

Chemical Property of 2-CHLORO-5-METHOXYBENZIMIDAZOLE

Chemical Property:

• Vapor Pressure: 1.54E-05mmHg at 25°C
• Melting Point: 167-169 °C
• Refractive Index: 1.656
• Boiling Point: 365.73 °C at 760 mmHg
• PKA: 8.73±0.10(Predicted)
• Flash Point: 174.988 °C
• PSA: 37.91000
• Density: 1.393 g/cm³
• LogP: 2.22490
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

2-Chloro-5-methoxybenzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 36/37/38-25-24-23
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-5-METHOXYBENZIMIDAZOLE

There total 4 articles about 2-CHLORO-5-METHOXYBENZIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxy-2-oxo-1,3-di-tert-butoxycarbonyl-2H-benzo[d]imidazole → 2-chloro-5-methoxy-1H-1,3-benzimidazole (15965-54-5)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield:

5-methoxy-1,3-dihydro-2H-benzoimidazol-2-one (2080-75-3) → 2-chloro-5-methoxy-1H-1,3-benzimidazole (15965-54-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; Heating;

DOI:10.1016/j.bmcl.2004.11.021

Reference yield:

4-methoxy-1,2-phenylenediamine (102-51-2) → 2-chloro-5-methoxy-1H-1,3-benzimidazole (15965-54-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 4 h / Heating

2: POCl₃; DBU / Heating

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.bmcl.2004.11.021

upstream raw materials:

5-methoxy-1,3-dihydro-2H-benzoimidazol-2-one

4-methoxy-1,2-phenylenediamine

Downstream raw materials:

2-chloro-5-hydroxybenzimidazole

5-methoxy-2-(4-methoxyphenyl)-1H-benzimidazole

4-[1-(5-Methoxy-1H-benzoimidazol-2-yl)piperidin-4-ylamino]benzoic acid tert-butyl ester

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