2080-75-3

Basic information

• Product Name: 5-METHOXY-2-BENZIMIDAZOLINONE
• Synonyms: BUTTPARK 121\04-68;1,3-Dihydro-5-methoxy-2H-benzimidazole-2-one~2-Hydroxy-5-methoxybenzimidazole;1,3-dihydro-5-methoxy-2h-benzimidazole-2-one;2H-Benzimidazol-2-one,1,3-dihydro-5-methoxy-(9CI);5-Methoxy-1H-benzimidazole-2(3H)-one;5-Methoxy-benzimidazolin-2-on;Omeprazole impurity R;5-Methoxy-1H-benzo[d]imidazol-2(3H)
• CAS NO: 2080-75-3
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.16
• Product Categories: BENZIMIDAZOLE;API intermediates;Aromatics Compounds;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 2080-75-3.mol
• Article Data: 11

Chemical Properties

• Melting Point: 255°C (dec.)
• Boiling Point: 174.5 °C at 760 mmHg
• Flash Point: 59.3 °C
• Appearance: Off-White Crystalline Solid
• Density: 1.252 g/cm³
• Vapor Pressure: 1.2mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: -20°C Freezer
• Solubility: DMSO, Methanol (Slightly)
• PKA: 11.53±0.30(Predicted)
• BRN: 141043
• CAS DataBase Reference: 5-METHOXY-2-BENZIMIDAZOLINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2-BENZIMIDAZOLINONE(2080-75-3)
• EPA Substance Registry System: 5-METHOXY-2-BENZIMIDAZOLINONE(2080-75-3)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• Hazardous Substances Data: 2080-75-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Crystalline Solid

Uses

Different sources of media describe the Uses of 2080-75-3 differently. You can refer to the following data:
1. 5-METHOXY-2-BENZIMIDAZOLINONE is a useful synthetic intermediate.
2. Benzimidazole derivative. An intermediate for a novel class of 2-{3-oxospiro[isobenzofuran -1(3H),4'-piperidin]-1'-yl}benzimidazole NPY Y5 receptor antagonist.
3. Benzimidazole derivative. An intermediate for a novel class of 2-{3-oxospiro[isobenzofuran-1(3H),4''-piperidin]-1''-yl}benzimidazole NPY Y5 receptor antagonist. An impurity of Esomeprazole, which is a gastric proton-pump inhibitor.

InChI:InChI=1/C8H8N2O2/c1-12-5-2-3-6-7(4-5)10-8(11)9-6/h2-4H,1H3,(H2,9,10,11)

Upstream product

• 124-38-9 carbon dioxide 
• 102-51-2 4-methoxy-1,2-phenylenediamine 
• 73590-58-6 omeprazole 
• 96-96-8 4-methoxy-2-nitroaniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 3360-81-4 N-(4-methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide 
• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 104-94-9 4-methoxy-aniline 
• 27185-61-1 N-(2-amino-4-methoxyphenyl)-4-methylbenzenesulfonamide 
• 57-13-6 urea 
• 623-49-4 ethyl cyanoformate 
• 1329028-11-6 C₁₄H₁₆N₂O₆ 
• 213118-56-0 (2-amino-4-methoxyphenyl)carbamate tert-butyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 64107-38-6 5-methoxy-1,3-dimethyl-1H-benzo[d]imidazol-2(3H)-one 
• 15965-54-5 2-chloro-5-methoxy-1H-1,3-benzimidazole 
• 1354030-44-6 5-(3-(4-(2,3-dichlorophenyl)-1,4-diazepan-1-yl)propoxy)-1H-benzo[d]imidazol-2(3H)-one 
• 1354030-54-8 5-(4-(4-(2,3-dichlorophenyl)piperidin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one 
• 1354030-70-8 5-(3-(4-(2,3-dichlorophenyl)piperazin-1-yl)propoxy)-1H-benzo[d]imidazol-2(3H)-one 
• 1354031-65-4 5-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-1H-benzo[d]imidazol-2(3H)-one 

Relevant articles and documents

Synthesis, radical scavenging activity and structure-activity relationship of uric acid analogs

Uric acid (UA) is known to play an important role as an endogenous antioxidant. However, its insolubility in the serum is a risk for hyperuricemia. We assume that UA is an equivalent to hydroquinone or p-aminophenol, which can be oxidized to quinone/quinoimine and thus acts as a radical scavenger. Based on this hypothesis, a series of UA analogs was designed and synthesized. In the chemical radical scavenging assay, active compounds were considered as hydroquinone or p-aminophenol equivalents. A highly functionalized UA structure is not essential to have radical scavenging activity. Potent active 5-hydroxyindolinones (1a, 2a, and 3a) showed sufficient activity with high solubility and low cytotoxicity.

NOVEL COMPOUNDS AND THEIR USES AS THYROID HORMONE RECEPTOR AGONISTS

A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto． (I), (Ia)

Azole-Anion-Based Aprotic Ionic Liquids: Functional Solvents for Atmospheric CO2 Transformation into Various Heterocyclic Compounds

The chemical transformation of atmospheric CO2 is of great significance yet still poses a great challenge. Herein, azole-anion-based aprotic ionic liquids (ILs) were synthesized by the deprotonation of weak proton donors (e.g., 2-methylimidazole, 4-methylimidazole, and 2,4-dimethylimidazole) with tetrabutylphosphonium hydroxide, [Bu4P][OH]. We found that these ILs, such as [Bu4P][2-MIm], could activate atmospheric CO2 through the formation of carbamates. The resultant carbamate intermediates could further react with various types of substrate, including propargylic alcohols, 2-aminobenzonitriles, ortho-phenylenediamines, and 2-aminothiophenol, thereby producing α-alkylidene cyclic carbonates, quinazoline-2,4(1 H,3 H)-diones, benzimidazolones, and benzothiazoline, respectively, in moderate-to-good yields. Thus, we have achieved the transformation of CO2 at atmospheric pressure, and we expect this method to open up new routes for the synthesis of various oxygen-containing heterocyclic compounds under metal-free conditions.