ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

Base Information

Chemical Name:ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate
CAS No.:1035262-71-5
Molecular Formula:C₁₇H₁₆ClNO₄
Molecular Weight:333.771
Hs Code.:

Synonyms:ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

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Chemical Property of ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

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Technology Process of ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

There total 4 articles about ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035262-70-4
2-(4-chloro-2-ethynylphenyl)propanenitrile

: 541-41-3
chloroformic acid ethyl ester

: 1035262-71-5
ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

Guidance literature:: 2-(4-chloro-2-ethynylphenyl)propanenitrile; With n-butyllithium; diisopropylamine; In tetrahydrofuran; at -78 ℃; for 0.333333h;

chloroformic acid ethyl ester; In tetrahydrofuran; at -78 - 20 ℃; for 0.333333h;

Reference yield:

: 882689-31-8
2-(4-chloro-2-iodophenyl)acetonitrile

: 1035262-71-5
ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium t-butanolate / tetrahydrofuran / 0.17 h / 0 °C

1.2: 0.17 h

2.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 3 h / 70 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 1 h

4.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.33 h / -78 °C

4.2: 0.33 h / -78 - 20 °C

With sodium hydroxide; n-butyllithium; water; triethylamine; diisopropylamine; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;

Reference yield:

: 1035262-68-0
2-(4-chloro-2-iodophenyl)propanenitrile

: 1035262-71-5
ethyl 3-(5-chloro-2-(2-cyano-1-ethoxy-1-oxopropan-2-yl)phenyl)propiolate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / 3 h / 70 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 1 h

3.1: n-butyllithium; diisopropylamine / tetrahydrofuran / 0.33 h / -78 °C

3.2: 0.33 h / -78 - 20 °C

With sodium hydroxide; n-butyllithium; water; triethylamine; diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran;