BOC-8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

Base Information

• Chemical Name: BOC-8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE
• CAS No.: 137469-86-4
• Molecular Formula: C14H20 N2 O2
• Molecular Weight: 248.325
• Hs Code.: 2933499090
• Mol file: 137469-86-4.mol

Synonyms:8-[(tert-Butoxycarbonyl)amino]-1,2,3,4-tetrahydroquinoline

Chemical Property of BOC-8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 338.4°Cat760mmHg
• Flash Point: 158.5°C
• PSA: 50.36000
• Density: 1.122g/cm³
• LogP: 3.60270

Purity/Quality:

98.5% ^*data from raw suppliers

Boc-8-amino-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE

There total 5 articles about BOC-8-AMINO-1,2,3,4-TETRAHYDROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.26%

8-amino-1,2,3,4-tetrahydroquinoline (54012-92-9) + di-tert-butyl dicarbonate (24424-99-5) → 8-(N-tert-Butoxycarbonylamino)-1,2,3,4-tetrahydroquinoline (137469-86-4)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 3h;

DOI:10.1016/j.ejmech.2020.112243

Reference yield:

8-amino quinoline (578-66-5) → 8-(N-tert-Butoxycarbonylamino)-1,2,3,4-tetrahydroquinoline (137469-86-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dioxane / 72 h / Heating

2: H₂ / 10percent Pd/C / methanol / 2280 Torr

With hydrogen; palladium on activated charcoal; In 1,4-dioxane; methanol;

Reference yield:

tert-butyl (quinolin-8-yl)carbamate (137469-85-3) → 8-(N-tert-Butoxycarbonylamino)-1,2,3,4-tetrahydroquinoline (137469-86-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 2280 Torr;

upstream raw materials:

tert-butyl (quinolin-8-yl)carbamate

8-amino quinoline

di-tert-butyl dicarbonate

8-amino-1,2,3,4-tetrahydroquinoline

Refernces

• 1、 -. "Chemokine receptor binding heterocyclic compounds". Page column 35-36. . Retrieved 2008/06/13.
• 2、 Bertrand, J. Jean-Claude,Just, George. "Synthesis of Bi- and Tri-cyclic Tetrazepinones". . p. 2525 - 2529. Retrieved 2007/10/02.