{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

Base Information

Chemical Name:{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester
CAS No.:914308-85-3
Molecular Formula:C₂₃H₁₉FN₆O₂S
Molecular Weight:462.507
Hs Code.:

Synonyms:{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

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Chemical Property of {5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

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Technology Process of {5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

There total 7 articles about {5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 914308-84-2
4-chloro-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidine-5-carbonitrile

: 623-51-8
ethyl 2-sulfanylacetate

: 914308-85-3
{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;

Reference yield:

: 456-41-7
1-(Bromomethyl)-3-fluorobenzene

: 914308-85-3
{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 20 °C

1.2: 12 h / 0 - 20 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

4.1: triethylamine / tetrahydrofuran

With hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 529508-58-5
1-(3-fluorobenzyl)-5-nitro-1H-carbazole

: 914308-85-3
{5-cyano-6-[1-(3-fluoro-benzyl)-1H-indazol-5-ylamino]-pyrimidin-4-ylsulfanyl}-acetic acidethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

3: triethylamine / tetrahydrofuran

With hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; In tetrahydrofuran; methanol;