(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Base Information

Chemical Name:(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
CAS No.:1073495-62-1
Molecular Formula:C₂₆H₂₉F₂N₃O
Molecular Weight:437.533
Hs Code.:

Synonyms:(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Suppliers and Price of (1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

There total 11 articles about (1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 944407-25-4
(1R)-1-({4-amino-1-piperidinyl}methyl)-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

: 245070-85-3
3-(3-fluorophenyl)propanal

: 1073495-62-1
(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: (1R)-1-({4-amino-1-piperidinyl}methyl)-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one; 3-(3-fluorophenyl)propanal; With sodium sulfate; In methanol; dichloromethane; for 16.5h;

With methanol; sodium tris(acetoxy)borohydride; In dichloromethane; for 23.5h;

Reference yield:

: 944407-17-4
2-(7-fluoro-2-methoxyquinolin-8-yl)acetonitrile

: 1073495-62-1
(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: chloro-trimethyl-silane / 2.25 h / 79 °C

2.1: triethylamine / hexanes; acetonitrile / 3 h / 20 °C

3.1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / cyclohexane / 5 h / 86 °C

4.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 2 h / 50 - 80 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -70 - 10 °C

5.2: 0.5 h

6.1: N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride / chloroform / 3.5 h / 20 - 65 °C

7.1: hydrogenchloride / water / 0 - 20 °C

8.1: isopropylamine / methanol; acetonitrile / Resolution of racemate

9.1: sodium sulfate / methanol; dichloromethane / 16.5 h

9.2: 23.5 h

With hydrogenchloride; lithium aluminium tetrahydride; chloro-trimethyl-silane; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; sodium sulfate; isopropylamine; triethylamine; N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; Methanesulfonic anhydride; In tetrahydrofuran; methanol; hexanes; dichloromethane; chloroform; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 944407-15-2
7-fluoro-2-methoxy-8-methylquinoline

: 1073495-62-1
(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: N-Bromosuccinimide; dibenzoyl peroxide / α,α,α-trifluorotoluene / 1 h / 70 °C / Irradiation

2.1: N,N-dimethyl-formamide / 70 °C

3.1: chloro-trimethyl-silane / 2.25 h / 79 °C

4.1: triethylamine / hexanes; acetonitrile / 3 h / 20 °C

5.1: N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate / cyclohexane / 5 h / 86 °C

6.1: N,N,N',N'-tetramethylguanidine / N,N-dimethyl-formamide / 2 h / 50 - 80 °C

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -70 - 10 °C

7.2: 0.5 h

8.1: N-ethyl-N,N-diisopropylamine; Methanesulfonic anhydride / chloroform / 3.5 h / 20 - 65 °C

9.1: hydrogenchloride / water / 0 - 20 °C

10.1: isopropylamine / methanol; acetonitrile / Resolution of racemate

11.1: sodium sulfate / methanol; dichloromethane / 16.5 h

11.2: 23.5 h

With hydrogenchloride; N-Bromosuccinimide; lithium aluminium tetrahydride; chloro-trimethyl-silane; N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; sodium sulfate; isopropylamine; triethylamine; N-ethyl-N,N-diisopropylamine; N,N,N',N'-tetramethylguanidine; Methanesulfonic anhydride; dibenzoyl peroxide; In tetrahydrofuran; methanol; hexanes; dichloromethane; chloroform; cyclohexane; α,α,α-trifluorotoluene; water; N,N-dimethyl-formamide; acetonitrile;