3-(3-FLUORO-PHENYL)-PROPIONALDEHYDE

Base Information

• Chemical Name: 3-(3-FLUORO-PHENYL)-PROPIONALDEHYDE
• CAS No.: 245070-85-3
• Molecular Formula: C9H9 F O
• Molecular Weight: 152.168
• Mol file: 245070-85-3.mol

Synonyms:3-(3-Fluorophenyl)propionaldehyde;3-Fluorobenzenepropanal

Chemical Property of 3-(3-FLUORO-PHENYL)-PROPIONALDEHYDE

Chemical Property:

• Vapor Pressure: 0.31mmHg at 25°C
• Refractive Index: 1.49
• Boiling Point: 201.3°Cat760mmHg
• Flash Point: 83.3°C
• PSA: 17.07000
• Density: 1.084g/cm³
• LogP: 1.95720

Purity/Quality:

98.5% ^*data from raw suppliers

3-(3-Fluorophenyl)propionaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(3-FLUORO-PHENYL)-PROPIONALDEHYDE

There total 8 articles about 3-(3-FLUORO-PHENYL)-PROPIONALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

carbon monoxide (201230-82-2) + 3-fluorostyrene (350-51-6) → 2-(3'-fluorophenyl)propanal (494862-24-7) + 3-(3-fluorophenyl)propanal (245070-85-3)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; hydrogen; sodium 4-dodecylbenzenesulfonate; Sodium; 2-[bis-(2-diphenylphosphanyl-ethyl)-carbamoyl]-benzenesulfonate; In water; toluene; at 60 ℃; under 30003 Torr;

DOI:10.1016/j.cclet.2021.07.068

Reference yield: 91.0%

1-Fluoro-3-iodobenzene (1121-86-4) + allyl alcohol (107-18-6) → 3-(3-fluorophenyl)propanal (245070-85-3)

Guidance literature:

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1016/j.bmcl.2009.05.119

Reference yield: 77.0%

3-(3-fluorophenyl)propionyl chloride (148960-31-0) → 3-(3-fluorophenyl)propanal (245070-85-3)

Guidance literature:

With triethylsilane; tris(2,4,6-trimethylphenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In toluene; at 40 ℃; for 3h; Schlenk technique; Inert atmosphere;

DOI:10.1055/s-0032-1317155

upstream raw materials:

3-(3-fluorophenyl)propan-1-ol

1-Fluoro-3-iodobenzene

allyl alcohol

3-(3-fluorophenyl)propionyl chloride

Downstream raw materials:

(1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

5-(3-fluorobenzyl)-2-thiazolamine

(E)-3-(3-fluorophenyl)acrylaldehyde

C₂₂H₂₄FN₃O

Refernces

• 1、 Chen, Fen-Er,Gao, Peng,Ke, Miaolin,Liang, Guanfeng,Ru, Tong. "Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst". . . Retrieved 2021/08/26.
• 2、 -. "TETRAHYDRO-IMIDAZO QUINOLINE COMPOSITIONS AS CBP/P300 INHIBITORS". Paragraph 0098-0099. . Retrieved 2019/04/11.