Ethyl 5-cyano-1H-pyrrole-2-carboxylate

Base Information

• Chemical Name: Ethyl 5-cyano-1H-pyrrole-2-carboxylate
• CAS No.: 21635-99-4
• Molecular Formula: C₈H₈N₂O₂
• Molecular Weight: 164.164
• Hs Code.: 2933990090
• Mol file: 21635-99-4.mol

Synonyms:Pyrrole-2-carboxylicacid, 5-cyano-, ethyl ester (8CI);Ethyl 5-cyano-1H-pyrrole-2-carboxylate;

Chemical Property of Ethyl 5-cyano-1H-pyrrole-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.000183mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 328.9 °C at 760 mmHg
• Flash Point: 152.7 °C
• PSA: 65.88000
• Density: 1.24 g/cm³
• LogP: 1.06308
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl5-cyano-1H-pyrrole-2-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of Ethyl 5-cyano-1H-pyrrole-2-carboxylate

There total 3 articles about Ethyl 5-cyano-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

isocyanate de chlorosulfonyle (1189-71-5) + ethyl 1H-pyrrole-2-carboxylate (2199-43-1) → ethyl 5-cyano-1H-pyrrole-2-carboxylate (21635-99-4)

Guidance literature:

In N,N-dimethyl-formamide; acetonitrile; at -40 - 20 ℃; for 24h;

DOI:10.1021/jo400372c

Reference yield:

5-(hydroxyimino-methyl)-1H-pyrrole-2-carboxylic acid ethyl ester → ethyl 5-cyano-1H-pyrrole-2-carboxylate (21635-99-4)

Guidance literature:

In dichloromethane; acetic anhydride;

Reference yield:

→ ethyl 5-cyano-1H-pyrrole-2-carboxylate (21635-99-4)

Guidance literature:

5-Cyan-pyrrol-2-carbonylcyanid, A.;

DOI:10.1016/S0040-4020(01)82624-7

upstream raw materials:

isocyanate de chlorosulfonyle

ethyl 1H-pyrrole-2-carboxylate

Downstream raw materials:

5-carboxy-1H-pyrrole-2-carbonitrile

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