3-Amino-1,2-benzisoxazole-6-methanamine

Base Information

Chemical Name:3-Amino-1,2-benzisoxazole-6-methanamine
CAS No.:368426-78-2
Molecular Formula:C₈H₉N₃O
Molecular Weight:163.179
Hs Code.:
Mol file:368426-78-2.mol

Synonyms:6-(Aminomethyl)-1,2-benzisoxazol-3-amine;3-Amino-1,2-benzisoxazole-6-methanamine;

Suppliers and Price of 3-Amino-1,2-benzisoxazole-6-methanamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
3-Amino-1,2-benzisoxazole-6-methanamine
25 mg
$ 409.00

Biosynth Carbosynth
3-Amino-1,2-benzisoxazole-6-methanamine
10 mg
$ 205.00

Biosynth Carbosynth
3-Amino-1,2-benzisoxazole-6-methanamine
5 mg
$ 118.00

Biosynth Carbosynth
3-Amino-1,2-benzisoxazole-6-methanamine
2 mg
$ 59.00

Biosynth Carbosynth
3-Amino-1,2-benzisoxazole-6-methanamine
50 mg
$ 712.00

American Custom Chemicals Corporation
3-AMINO-1,2-BENZISOXAZOLE-6-METHANAMINE 95.00%
5MG
$ 501.37

AK Scientific
3-Amino-1,2-benzisoxazole-6-methanamine
50mg
$ 1011.00

Total 9 raw suppliers

Chemical Property of 3-Amino-1,2-benzisoxazole-6-methanamine

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.702
Boiling Point:388.272 °C at 760 mmHg
Flash Point:188.62 °C
PSA：78.80000
Density:1.339 g/cm³
LogP:1.49910

Purity/Quality:

98%Min ^*data from raw suppliers

3-Amino-1,2-benzisoxazole-6-methanamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 3-Amino-1,2-benzisoxazole-6-methanamine is used in the preparation of MASP-2 inhibitors.

Technology Process of 3-Amino-1,2-benzisoxazole-6-methanamine

There total 5 articles about 3-Amino-1,2-benzisoxazole-6-methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 229623-53-4,201157-76-8
6-cyano-3-amino-1,2-benzisoxazole

: 368426-78-2
6-aminomethyl-benzo[d]isoxazol-3-ylamine

Guidance literature:: With borane-THF; In tetrahydrofuran; at 60 ℃; for 1h;

Reference yield: 73.0%

: 1897-53-6
2-fluoroterephthalonitrile

: 368426-78-2
6-aminomethyl-benzo[d]isoxazol-3-ylamine

Guidance literature:: 2-fluoroterephthalonitrile; With acetylhydroxamic acid; potassium carbonate; In water; N,N-dimethyl-formamide; for 12h;

With borane-THF; In tetrahydrofuran; for 6h; Cooling;

With hydrogenchloride; In tetrahydrofuran; for 2h;
DOI:10.1021/acs.jmedchem.8b01381

Reference yield:

: 105942-08-3
4-bromo-6-fluorobenzonitrile

: 368426-78-2
6-aminomethyl-benzo[d]isoxazol-3-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / Heating

2: CH₃CONHOH; KO-t-Bu / dimethylformamide / 39 h / 20 - 70 °C

3: BH₃*THF / 15 h / 20 °C

With borane-THF; acetylhydroxamic acid; potassium tert-butylate; In N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(02)00585-1