1897-53-6

Basic information

• Product Name: 2-FLUOROTEREPHTHALONITRILE
• Synonyms: 2-FLUOROTEREPHTHALONITRILE;3-Fluoroterephthalonitrile;2-Fluoro-1,4-benzenedicarbonitrile;2-Fluorobenzene-1,4-dicarbonitrile
• CAS NO: 1897-53-6
• Molecular Formula: C₈H₃FN₂
• Molecular Weight: 146.12
• Mol File: 1897-53-6.mol

Chemical Properties

• Melting Point: 121.0-123.5 °C
• Boiling Point: 280.6°C at 760 mmHg
• Flash Point: 123.5°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 0.00376mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-FLUOROTEREPHTHALONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUOROTEREPHTHALONITRILE(1897-53-6)
• EPA Substance Registry System: 2-FLUOROTEREPHTHALONITRILE(1897-53-6)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 1897-53-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoroterephthalonitrile is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with improved therapeutic properties and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoroterephthalonitrile is utilized as a precursor for the production of pesticides and other agrochemicals. Its incorporation into these products enhances their effectiveness in controlling pests and diseases in agriculture.
Used in Dye and Pigment Industry:
2-Fluoroterephthalonitrile is employed as a building block in the synthesis of dyes and pigments, contributing to the development of new colorants with improved properties such as color strength, stability, and resistance to fading.
Used in Polymer Industry:
As a monomer or a building block, 2-Fluoroterephthalonitrile is used in the manufacturing of polymers with specific properties tailored for various applications, including high-performance materials for automotive, aerospace, and electronics industries.
Used in Organic Synthesis:
2-Fluoroterephthalonitrile serves as a versatile starting material in organic synthesis, enabling the development of new organic compounds with diverse applications in various industries, such as pharmaceuticals, materials science, and specialty chemicals.

InChI:InChI=1/C8H3FN2/c9-8-3-6(4-10)1-2-7(8)5-11/h1-3H

Upstream product

• 105942-08-3 4-bromo-6-fluorobenzonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 1435-52-5 2,5-dibromofluorobenzene 
• 557-21-1 zinc(II) cyanide 
• 164149-28-4 4-cyano-2-fluorobenzoic acid 
• 1046447-03-3 4-cyano-2-fluorobenzamide 
• 557-21-1 dicyanozinc 
• 544-92-3 copper(I) cyanide 

Downstream Products

• 267413-32-1 3-amino-6-cyanoindazole 
• 229623-53-4 6-cyano-3-amino-1,2-benzisoxazole 
• 368426-75-9 6-(aminomethyl)-1H-indazol-3-amine 
• 3906-87-4 2-fluoro-1,4-benzenedicarboxylic acid 
• 267413-21-8 O-(2,5-dicyanophenyl)-acetophenone oxime 
• 368426-78-2 6-aminomethyl-benzo[d]isoxazol-3-ylamine 

Relevant articles and documents

Preparation method of aromatic dicarboxylic acid derivative

The invention provides a preparation method of an aromatic dicarboxylic acid derivative, wherein the preparation method comprises the following steps: step 1, carrying out a coupling reaction on dihalogenated aromatic hydrocarbon and metal cyanide at a temperature of 40-200 DEG C under metal catalysis in a solvent, and carrying out extraction layering concentration to obtain a dicyano compound after the reaction is finished; and step 2, carrying out a hydrolysis reaction on the obtained dicyanogen compound at the temperature of 60-200 DEG C under an acidic condition, and carrying out post-treatment to obtain the final product. According to the preparation method of the aromatic dicarboxylic acid derivative, dihalogenated aromatic hydrocarbon reacts with metal cyanide and then is hydrolyzedunder the acidic condition to obtain aromatic acid or the derivative thereof, and the preparation method has the remarkable advantages that the raw materials are cheap and easy to obtain, operation is easy and convenient, the yield is high, three wastes are easy to dispose, the product quality is high, and the substrate tolerance is good.

Improving the Selectivity of PACE4 Inhibitors through Modifications of the P1 Residue

Paired basic amino acid cleaving enzyme 4 (PACE4), a serine endoprotease of the proprotein convertases family, has been recognized as a promising target for prostate cancer. We previously reported a selective and potent peptide-based inhibitor for PACE4, named the multi-Leu peptide (Ac-LLLLRVKR-NH2 sequence), which was then modified into a more potent and stable compound named C23 with the following structure: Ac-dLeu-LLLRVK-Amba (Amba: 4-amidinobenzylamide). Despite improvements in both in vitro and in vivo profiles of C23, its selectivity for PACE4 over furin was significantly reduced. We examined other Arg-mimetics instead of Amba to regain the lost selectivity. Our results indicated that the replacement of Amba with 5-(aminomethyl)picolinimidamide increased affinity for PACE4 and restored selectivity. Our results also provide a better insight on how structural differences between S1 pockets of PACE4 and furin could be employed in the rational design of selective inhibitors.

COMPOUND, MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS, ORGANIC ELECTROLUMINESCENT ELEMENT, AND ELECTRONIC DEVICE

A compound is represented by a formula (1) below, in which k is an integer of 0 or more, m is an integer of 1 or more, n is an integer of 2 or more. L is a substituted or unsubstituted aromatic hydrocarbon ring having 6 to 30 ring carbon atoms, CN is a cyano group, and D1 and D2 are each independently represented by one of a formula (2), a formula (3) and formula (3x) below, D1 and D2 being optionally mutually the same or different.

Palladium/N-Heterocyclic carbene catalyzed mono- and double-cyanation of aryl halides using potassium ferrocyanide trihydrate under aerobic conditions

Abstract A practical palladium/N-heterocyclic carbene catalyzed procedure for the mono- and double-cyanation of aryl halides is described using inexpensive, easy-to-handle and nontoxic potassium ferrocyanide trihydrate {K4[Fe(CN)6]·3H2O} as the cyanating agent. The reaction does not require an anhydrous solvent, or the exclusion of air or moisture. A variety of electron-rich and electron-deficient aryl halides are efficiently converted into their corresponding nitriles and dicarbonitriles.

ANTIPARASITIC AGENTS

The present invention relates to compounds of the formula (I) or a tautomer or prodrug thereof, or a pharmaceutically acceptable salt of said compound, tautomer or prodrug, wherein: R1, R2, R3, R4 and R5 are each independently selected from H, halo, CN, CF3 and CONH2; compositions containing such compounds and the uses of such compounds as antiparasitic agents.

HETERO COMPOUND

[Problems] To provide a useful compound as an active ingredient for a preventing and/or treating agent for rejection in the transplantation of an organ, bone marrow, or a tissue, an autoimmune disease, or the like, which has an excellent S1P1 a

PYRIDINES AND PYRIDINE N-OXIDES AS MODULATORS OF THROMBIN

The present invention describes compounds of Formula I: wherein W, X, Y, Z, and Q are defined herein, or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity in a mammal.

Non-covalent thrombin inhibitors featuring P3-heterocycles with P1-bicyclic arginine surrogates

Novel, potent, and highly selective classes of thrombin inhibitors were identified, which resulted from judicious combination of P4-aromatics and P2-P3-heterocyclic dipeptide surrogates with weakly basic (calcd pKa ～non-basic - 8.6) bicyclic P1-arginine mimics. The design, synthesis, and biological activity of achiral, non-covalent, orally bioavailable inhibitors NC1-NC44 featuring P1-indazoles, benzimidazoles, indoles, benzotriazoles, and aminobenzisoxazoles is disclosed.

ANTICOAGULANT AGENTS

This invention relates to a compound of the Formula I X--C(O)--Y--G--R I(wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound