1-Benzylpiperazin-2-one hydrochloride

Base Information

• Chemical Name: 1-Benzylpiperazin-2-one hydrochloride
• CAS No.: 78551-58-3
• Molecular Formula: C11H14 N2 O . Cl H
• Molecular Weight: 226.706
• Hs Code.: 2933599090
• Mol file: 78551-58-3.mol

Synonyms:Piperazinone,1-(phenylmethyl)-, monohydrochloride (9CI); 1-Benzyl-2-oxopiperazinehydrochloride

Chemical Property of 1-Benzylpiperazin-2-one hydrochloride

Chemical Property:

• Vapor Pressure: 5.45E-07mmHg at 25°C
• Boiling Point: 406.1°C at 760 mmHg
• Flash Point: 199.4°C
• PSA: 32.34000
• LogP: 1.68710
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-Benzylpiperazin-2-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Benzylpiperazin-2-one hydrochloride

There total 5 articles about 1-Benzylpiperazin-2-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-Benzyl-4-chloroacetyl-2-piperazinone (107235-76-7) → 1-(Phenylmethyl)piperazinone hydrochloride (78551-58-3)

Guidance literature:

With 1,2-diamino-benzene; In ethanol; for 2h; Heating;

DOI:10.1007/BF00542783

Reference yield:

1,4-Bis(phenylmethyl)piperazinone, hydrochloride → 1-(Phenylmethyl)piperazinone hydrochloride (78551-58-3)

Guidance literature:

palladium charcoal; In ethanol;

Reference yield:

N-Benzyl-N,N'-bis(chloroacetyl)ethylendiamine (107235-77-8) → 1-(Phenylmethyl)piperazinone hydrochloride (78551-58-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / potassium tert-butylate / 2-methyl-propan-2-ol / 0.33 h / Ambient temperature

2: 60 percent / o-phenylendiamine / aq. ethanol / 2 h / Heating

With potassium tert-butylate; 1,2-diamino-benzene; In ethanol; tert-butyl alcohol;

DOI:10.1007/BF00542783

upstream raw materials:

1-Benzyl-4-chloroacetyl-2-piperazinone

N-Benzyl-N,N'-bis(chloroacetyl)ethylendiamine

N-benzylethylenediamine

benzyl bromide

Downstream raw materials:

4-Benzoyl-1-benzyl-2-piperazinone

1-benzyl-4-(tert-butyloxycarbonyl)piperazin-2-one

4-(4-Nitrobenzoyl)-1-benzyl-2-piperazinone

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