5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol

Base Information

• Chemical Name: 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol
• CAS No.: 1022949-63-8
• Molecular Formula: C₂₆H₃₂ClN₅O₄S
• Molecular Weight: 546.09

Synonyms:5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol

Chemical Property of 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol

Chemical Property:

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Technology Process of 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol

There total 9 articles about 5-chloro-N₄-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N₂-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(8-methoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)pyrimidine-2,4-diamine + 2-bromoethanol (540-51-2) → 5-chloro-N4-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N2-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol (1022949-63-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2015.07.004

Reference yield:

8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine (37682-06-7) → 5-chloro-N4-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N2-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol (1022949-63-8)

Guidance literature:

Multi-step reaction with 6 steps

1: trifluoroacetic anhydride; HK*NO₃^(1-) / acetonitrile / 20 °C

2: borane / tetrahydrofuran / Reflux

3: triethylamine / dichloromethane / 20 °C

4: hydrogen; palladium 10% on activated carbon / 20 °C

5: hydrogenchloride / 2-ethoxy-ethanol; 1,4-dioxane / 80 °C

6: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; HK*NO₃^(1-); borane; hydrogen; caesium carbonate; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.bmcl.2015.07.004

Reference yield:

7-Nitro-8-methoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one → 5-chloro-N4-((2-((isopropylsulfonyl)phenylamino)pyrimidin-2-yl)amino-N2-8-methoxy-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)ethanol (1022949-63-8)

Guidance literature:

Multi-step reaction with 5 steps

1: borane / tetrahydrofuran / Reflux

2: triethylamine / dichloromethane / 20 °C

3: hydrogen; palladium 10% on activated carbon / 20 °C

4: hydrogenchloride / 2-ethoxy-ethanol; 1,4-dioxane / 80 °C

5: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; borane; hydrogen; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; 2-ethoxy-ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2015.07.004

upstream raw materials:

2,3-dihydro-8-methoxy-2-oxo-1H-3-benzazepine

8-methoxy-2,3,4,5-tetrahydro-2-oxo-1H-3-benzazepine

7-methoxy-8-nitro-2,3,4,5-tetrahydro1H-benzo[d]iazepine

2,2,2-trifluoro-1-(7-methoxy-8-nitro-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-ethanone

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