3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

Base Information

Chemical Name:3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate
CAS No.:447425-72-1
Molecular Formula:C₂₆H₂₉F₃N₂O₆S
Molecular Weight:554.587
Hs Code.:

Synonyms:3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

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Chemical Property of 3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

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Technology Process of 3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

There total 11 articles about 3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 447425-68-5
tert-butyl {[7-hydroxy-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate

: 447425-72-1
3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: tert-butyl {[7-hydroxy-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-3-yl]methyl}carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

N,N-phenylbistrifluoromethane-sulfonimide; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: C₂₇H₂₄ClNO₃

: 447425-72-1
3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tetrahydroborate / tetrahydrofuran; 1,2-dimethoxyethane / 1 h / 0 °C

2.1: thionyl chloride / toluene / 2 h / Reflux

3.1: N,N-dimethyl-formamide / 6 h / 20 °C

4.1: hydrazine hydrate / ethanol / 1 h / Reflux

5.1: tetrahydrofuran / 1 h / 20 °C

6.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

7.2: 6 h / 20 °C

With sodium tetrahydroborate; thionyl chloride; 5%-palladium/activated carbon; hydrogen; sodium hydride; hydrazine hydrate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2011.06.059

Reference yield:

: 447425-65-2
7-(benzyloxy)-3-(chloromethyl)-2-(2-methylpropyl)-4-phenylisoquinolin-1(2H)-one

: 447425-72-1
3-{[(tert-butoxycarbonyl)amino]methyl}-2-(2-methylpropyl)-1-oxo-4-phenyl-1,2-dihydroisoquinolin-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 6 h / 20 °C

2.1: hydrazine hydrate / ethanol / 1 h / Reflux

3.1: tetrahydrofuran / 1 h / 20 °C

4.1: 5%-palladium/activated carbon; hydrogen / tetrahydrofuran; ethanol / 2 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

5.2: 6 h / 20 °C

With 5%-palladium/activated carbon; hydrogen; sodium hydride; hydrazine hydrate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.06.059