2-(benzylamino)-4-Quinazolinol

Base Information

• Chemical Name: 2-(benzylamino)-4-Quinazolinol
• CAS No.: 1791-50-0
• Molecular Formula: C₁₅H₁₃N₃O
• Molecular Weight: 251.288
• Mol file: 1791-50-0.mol

Synonyms:2-(benzylamino)-4-Quinazolinol

Chemical Property of 2-(benzylamino)-4-Quinazolinol

Chemical Property:

Purity/Quality:

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Technology Process of 2-(benzylamino)-4-Quinazolinol

There total 14 articles about 2-(benzylamino)-4-Quinazolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-ethoxy-3,4-dihydro-4-oxoquinazoline (13300-22-6) + benzylamine (100-46-9) → 2-(benzylamino)-4-Quinazolinol (1791-50-0)

Guidance literature:

In toluene; for 24h; Heating;

Reference yield: 87.0%

2-isocyanobenzamide + benzylamine (100-46-9) → 2-(benzylamino)-4-Quinazolinol (1791-50-0)

Guidance literature:

With oxygen; palladium diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 5h; under 760.051 Torr; Reagent/catalyst;

DOI:10.1002/anie.201303213

Reference yield: 83.0%

2-chloro-4(3H)-quinazolinone (607-69-2) + benzylamine (100-46-9) → 2-(benzylamino)-4-Quinazolinol (1791-50-0)

Guidance literature:

In N,N-dimethyl-formamide; at 80 - 100 ℃;

DOI:10.1021/jm00155a007

upstream raw materials:

2-chloro-4(3H)-quinazolinone

benzylamine

2-ethoxy-3,4-dihydro-4-oxoquinazoline

2-methylthioquinazolin-4(3H)-one