[4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine

Base Information

• Chemical Name: [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine
• CAS No.: 171285-38-4
• Molecular Formula: C₂₃H₃₁BrN₂O
• Molecular Weight: 431.416
• Mol file: 171285-38-4.mol

Synonyms:[4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine

Chemical Property of [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine

There total 6 articles about [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(+/-)-7-bromo-8-methoxy-3-<4-(N,N-dimethylamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine (171285-34-0) → [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine (171285-38-4)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1021/jm00021a018

Reference yield:

styrene oxide (96-09-3) → [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine (171285-38-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 45 percent / acetonitrile / 18 h / Heating

2: 90 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

3: 65 percent / 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate, Et₃N / dimethylformamide / 48 h / Ambient temperature

4: 90 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonic acid; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00021a018

Reference yield:

(3-bromo-4-methoxyphenyl)-acetonitrile (772-59-8) → [4-(7-Bromo-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-butyl]-dimethyl-amine (171285-38-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 90 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 1 h / Ambient temperature

2: 45 percent / acetonitrile / 18 h / Heating

3: 90 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

4: 65 percent / 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate, Et₃N / dimethylformamide / 48 h / Ambient temperature

5: 90 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonic acid; sulfuric acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm00021a018

upstream raw materials:

(+/-)-7-bromo-8-methoxy-3-<4-(N,N-dimethylamino)butanoyl>-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

styrene oxide

(3-bromo-4-methoxyphenyl)-acetonitrile

3-Bromo-4-methoxyphenethylamine