772-59-8 Usage
General Description
3-Bromo-4-methoxyphenylacetonitrile is an organic compound with the molecular formula C9H8BrNO, characterized by its 3-bromo-4-methoxyphenyl group bonded with an acetonitrile group. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3-BROMO-4-METHOXYPHENYLACETONITRILE has a wide range of applications, including in the production of active pharmaceutical ingredients, specifically in the development of medical drugs and pharmaceutical formulations. Additionally, it may also serve as a building block for the synthesis of various organic compounds in the chemical industry. Due to its chemical structure and reactivity, 3-bromo-4-methoxyphenylacetonitrile is carefully handled and used under controlled conditions to ensure safety and proper handling.
Check Digit Verification of cas no
The CAS Registry Mumber 772-59-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,7 and 2 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 772-59:
(5*7)+(4*7)+(3*2)+(2*5)+(1*9)=88
88 % 10 = 8
So 772-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H8BrNO/c1-12-9-3-2-7(4-5-11)6-8(9)10/h2-3,6H,4H2,1H3
772-59-8Relevant articles and documents
Palladium-Catalyzed, ortho-Selective C-H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides
Das, Riki,Kapur, Manmohan
, p. 1114 - 1126 (2018/06/18)
A palladium-catalyzed, ortho-selective C-H halogenation methodology is reported herein. The highlight of the work is the highly selective C(sp2)-H functionalization of benzyl nitriles in the presence of activated C(sp3)-H bond, which results in good yields of the halogenated products with excellent regioselectivity. Along with benzyl nitriles, aryl Weinreb amides and anilides have been evaluated for the transformation using aprotic conditions. Mechanistic studies yield interesting aspects with respect to the pathway of the reaction and the directing group abilities.
