N-Phenylpyrrolidin-3-amine

Base Information

• Chemical Name: N-Phenylpyrrolidin-3-amine
• CAS No.: 17741-13-8
• Molecular Formula: C10H14 N2
• Molecular Weight: 162.23
• Hs Code.: 2933990090
• Mol file: 17741-13-8.mol

Synonyms:Pyrrolidine,3-anilino- (8CI)

Chemical Property of N-Phenylpyrrolidin-3-amine

Chemical Property:

• Vapor Pressure: 0.00156mmHg at 25°C
• Boiling Point: 295.1°C at 760 mmHg
• Flash Point: 175.1°C
• PSA: 24.06000
• Density: 1.083g/cm³
• LogP: 1.86220

Purity/Quality:

98%min ^*data from raw suppliers

N-phenylpyrrolidin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Phenylpyrrolidin-3-amine

There total 5 articles about N-Phenylpyrrolidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(tert-butoxycarbonyl)-3-(phenylamino)pyrrolidine (816468-24-3) → 3-(phenylamino)pyrrolidine (17741-13-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jo0487193

Reference yield:

bromobenzene (108-86-1,52753-63-6) + pyrrolidin-3-amine (79286-79-6) → 1-phenyl-3-(phenylamino)pyrrolidine + 3-(phenylamino)pyrrolidine (17741-13-8) + 3-amino-1-phenylpyrrolidine (18471-41-5)

Guidance literature:

With Josiphos-type ferrocene; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In xylene; at 130 ℃; for 24h; Title compound not separated from byproducts;

DOI:10.1021/jo062301i

Reference yield:

bromobenzene (108-86-1,52753-63-6) → 3-(phenylamino)pyrrolidine (17741-13-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / Pd₂(dba)3; 2-dicyclohexylphosphinobiphenyl; t-BuONa / xylene / 24 h / 130 °C

2: 85 percent / CF₃CO₂H / CH₂Cl₂ / 12 h / 20 °C

With tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; trifluoroacetic acid; sodium t-butanolate; CyJohnPhos; In dichloromethane; xylene;

DOI:10.1021/jo0487193

upstream raw materials:

1-(tert-butoxycarbonyl)-3-(phenylamino)pyrrolidine

bromobenzene

pyrrolidin-3-amine

chlorobenzene

Refernces

• 1、 Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire. "Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines". . p. 8893 - 8902. Retrieved 2007/10/03.