(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Base Information

Chemical Name:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride
CAS No.:1307310-10-6
Molecular Formula:C₂₉H₃₄N₄O₂*ClH
Molecular Weight:507.075
Hs Code.:

Synonyms:(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

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Chemical Property of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

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Technology Process of (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

There total 15 articles about (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1307310-09-3
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile

: 1307310-10-6
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: (S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carbonitrile; With sodium methylate; In methanol; at 20 - 50 ℃; for 24h; Inert atmosphere;

With ammonium chloride; In methanol; at 50 ℃; Inert atmosphere;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-02-6
2-bromo-1-(3-(2-cyclohexylethyl)phenyl)ethanone

: 1307310-10-6
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / ethanol / 0.1 h / 20 °C / Sonication; Inert atmosphere

1.2: 12 h / 20 °C / Inert atmosphere

2.1: ammonium acetate; acetic acid / 16 h / Reflux; Inert atmosphere

3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

4.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

4.2: 50 °C / Inert atmosphere

With ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; sodium methylate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm2001053

Reference yield:

: 1307310-01-5
1-(3-(2-cyclohexylethyl)phenyl)ethanone

: 1307310-10-6
(S)-1-(4-(4-(3-(2-cyclohexylethyl)phenyl)oxazol-2-yl)benzoyl)pyrrolidine-2-carboximidamide hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / chloroform / 40 °C / Inert atmosphere

2.1: caesium carbonate / ethanol / 0.1 h / 20 °C / Sonication; Inert atmosphere

2.2: 12 h / 20 °C / Inert atmosphere

3.1: ammonium acetate; acetic acid / 16 h / Reflux; Inert atmosphere

4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

5.1: sodium methylate / methanol / 24 h / 20 - 50 °C / Inert atmosphere

5.2: 50 °C / Inert atmosphere

With ammonium acetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; sodium methylate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; chloroform;
DOI:10.1021/jm2001053