tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate
CAS No.:1333405-34-7
Molecular Formula:C₃₃H₄₁N₅O₄
Molecular Weight:571.72
Hs Code.:

Synonyms:tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

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Technology Process of tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

There total 8 articles about tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1333405-33-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

: 1333405-34-7
tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethanol; at 25 ℃; for 18h;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-30-3
3-benzyl-6-bromo-5-methyl-2-propylpyrrolo[2,3-e]pyrimidin-4-one

: 1333405-34-7
tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

2: triethylamine / dichloromethane / 120 h / 25 °C

3: triethylamine / dichloromethane / 12 h / 25 °C

4: 5%-palladium/activated carbon; hydrogen / ethanol / 18 h / 25 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrachloromethane; ethanol; dichloromethane;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-26-7
ethyl 3-(butanoylamino)-1-methylpyrrole-2-carboxylate

: 1333405-34-7
tert-butyl N-[3-[1-(3-benzyl-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium hydroxide / 6 h / 110 - 115 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 16 h / Reflux

2.2: 0.08 h / 65 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

4.1: triethylamine / dichloromethane / 120 h / 25 °C

5.1: triethylamine / dichloromethane / 12 h / 25 °C

6.1: 5%-palladium/activated carbon; hydrogen / ethanol / 18 h / 25 °C

With ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); 5%-palladium/activated carbon; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In tetrachloromethane; ethanol; dichloromethane; toluene;
DOI:10.1021/jm200629m