tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Base Information

Chemical Name:tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate
CAS No.:1333405-33-6
Molecular Formula:C₃₃H₄₀BrN₅O₄
Molecular Weight:650.616
Hs Code.:

Synonyms:tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

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Chemical Property of tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

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Technology Process of tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

There total 7 articles about tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1333405-32-5
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propylamino]propyl]carbamate

: 874-60-2
4-methyl-benzoyl chloride

: 1333405-33-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 25 ℃; for 12h;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-30-3
3-benzyl-6-bromo-5-methyl-2-propylpyrrolo[2,3-e]pyrimidin-4-one

: 1333405-33-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

2: triethylamine / dichloromethane / 120 h / 25 °C

3: triethylamine / dichloromethane / 12 h / 25 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); triethylamine; In tetrachloromethane; dichloromethane;
DOI:10.1021/jm200629m

Reference yield:

: 1333405-26-7
ethyl 3-(butanoylamino)-1-methylpyrrole-2-carboxylate

: 1333405-33-6
tert-butyl N-[3-[1-(3-benzyl-6-bromo-5-methyl-4-oxopyrrolo[3,2-d]pyrimidin-2-yl)propyl-(4-methylbenzoyl)amino]propyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium hydroxide / 6 h / 110 - 115 °C

2.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / toluene / 16 h / Reflux

2.2: 0.08 h / 65 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 0.75 h / Reflux

4.1: triethylamine / dichloromethane / 120 h / 25 °C

5.1: triethylamine / dichloromethane / 12 h / 25 °C

With ammonium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; triethylamine; In tetrachloromethane; dichloromethane; toluene;
DOI:10.1021/jm200629m