A,A-DIMETHYL-4-[4-[4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL]-1-OXOBUTYL]PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: A,A-DIMETHYL-4-[4-[4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL]-1-OXOBUTYL]PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE
• CAS No.: 169280-33-5
• Molecular Formula: C33H39 N O4 . Cl H
• Molecular Weight: 550.138
• Mol file: 169280-33-5.mol

Synonyms:Benzeneaceticacid, 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-a,a-dimethyl-,methyl ester, hydrochloride (9CI)

Chemical Property of A,A-DIMETHYL-4-[4-[4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL]-1-OXOBUTYL]PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.89E-19mmHg at 25°C
• Boiling Point: 677.2°C at 760 mmHg
• Flash Point: 363.4°C
• PSA: 66.84000
• LogP: 6.48810

Purity/Quality:

99% ^*data from raw suppliers

A,A-DIMETHYL-4-(4-(4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL)-1-OXOBUTYL)PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of A,A-DIMETHYL-4-[4-[4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL]-1-OXOBUTYL]PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE

There total 1 articles about A,A-DIMETHYL-4-[4-[4-(HYDROXYDIPHENYL METHYL)-1-PIPERIDINYL]-1-OXOBUTYL]PHENYL ACETIC ACID METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C18H21NO (115-46-8) + 2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester (154477-54-0) → 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-oxobutyl]-α,α-dimethylbenzeneacetic acid, methyl ester hydrochloride (169280-33-5)

Guidance literature:

In toluene; for 29h; Heating / reflux;

Reference yield: 94.0%

4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-oxobutyl]-α,α-dimethylbenzeneacetic acid, methyl ester hydrochloride (169280-33-5) → 4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, methyl ester hydrochloride (343255-29-8)

Guidance literature:

4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-oxobutyl]-α,α-dimethylbenzeneacetic acid, methyl ester hydrochloride; With sodium tetrahydroborate; In methanol; for 1h;

With sodium hydroxide; for 3h; Heating / reflux;

upstream raw materials:

C₁₈H₂₁NO

2-[4-(4-Chloro-butyryl)-phenyl]-2-methyl-propionic acid, methyl ester

Downstream raw materials:

4-[4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-α,α-dimethylbenzeneacetic acid, methyl ester hydrochloride