NALTRINDOLE HYDROCHLORIDE

Base Information

• Chemical Name: NALTRINDOLE HYDROCHLORIDE
• CAS No.: 111469-81-9
• Molecular Formula: C26H26 N2 O3 . Cl H
• Molecular Weight: 450.965
• Mol file: 111469-81-9.mol

Synonyms:4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol,7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-, monohydrochloride,(4bS,8R,8aS,14bR)- (9CI); Naltrindole hydrochloride

Chemical Property of NALTRINDOLE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.51E-18mmHg at 25°C
• Boiling Point: 664.2°Cat760mmHg
• Flash Point: 355.5°C
• PSA: 68.72000
• Density: g/cm³
• LogP: 4.31250
• Storage Temp.: −20°C
• Solubility.: methanol: 4.5 mg/mL

Purity/Quality:

98%,99%, ^*data from raw suppliers

Naltrindole Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Naltrindole Hydrochloride is a δ opioid (DOR) receptor antagonist.

Technology Process of NALTRINDOLE HYDROCHLORIDE

There total 1 articles about NALTRINDOLE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

naltrexone Hydrochloride (16676-29-2) + phenylhydrazine hydrochloride (59-88-1) → naltrindole hydrochloride (111469-81-9)

Guidance literature:

In water; for 0.75h; Reflux;

DOI:10.1039/b920864j

Reference yield:

naltrindole hydrochloride (111469-81-9) → 14-[(2-chlorobenzyl)oxy]-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxyindolo[2',3':6,7]morphinan-3-ol hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 15 min, r.t., 30 min; 2.) 0 deg C, 30 min, r.t., 120 min

2: 1.) NaH / 1.) DMF, 0 deg C, 15 min, r.t., 30 min; 2.) 0 deg C, 15 min, r.t., 3 h

3: 43 percent / 1N HCl / methanol / 1 h / Heating

With hydrogenchloride; sodium hydride; In methanol;

DOI:10.1002/hlca.19980810532

Reference yield:

naltrindole hydrochloride (111469-81-9) → 14-[(2-chlorobenzyl)oxy]-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3-(methoxymethoxy)-1'-(methoxymethyl)indolo[2',3':6,7]morphinan (173782-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 15 min, r.t., 30 min; 2.) 0 deg C, 30 min, r.t., 120 min

2: 1.) NaH / 1.) DMF, 0 deg C, 15 min, r.t., 30 min; 2.) 0 deg C, 15 min, r.t., 3 h

With sodium hydride;

DOI:10.1002/hlca.19980810532

upstream raw materials:

naltrexone Hydrochloride

phenylhydrazine hydrochloride

Downstream raw materials:

14-[(2-chlorobenzyl)oxy]-17-(cyclopropylmethyl)-6,7-didehydro-4,5α-epoxy-3-(methoxymethoxy)-1'-(methoxymethyl)indolo[2',3':6,7]morphinan

Refernces

• 1、 Portoghese,Sultana,Takemori. "Design of peptidomimetic δ opioid receptor antagonists using the message-address concept". . p. 1714 - 1720. Retrieved 2007/10/02.