2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine

Base Information

• Chemical Name: 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine
• CAS No.: 1438286-74-8
• Molecular Formula: C₁₇H₁₈BrNO₄
• Molecular Weight: 380.238
• Mol file: 1438286-74-8.mol

Synonyms:2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine

Chemical Property of 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine

There total 3 articles about 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide (1170045-84-7) + 2-bromo-6-iodo-3-methoxypyridine (321535-37-9) → 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine (1438286-74-8)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 3h; Sealed tube;

DOI:10.1021/acs.jmedchem.8b00050

Reference yield: 55.0%

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide (1170045-84-7) + 2,6-dibromo-3-methoxylpyridine (79491-45-5) → 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine (1438286-74-8)

Guidance literature:

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide; With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; at 20 ℃; for 0.0833333h; Inert atmosphere; Sealed tube;

2,6-dibromo-3-methoxylpyridine; With lithium tert-butoxide; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere; Sealed tube;

DOI:10.1039/c3ob40263k

Reference yield:

methyl (3,4,5-trimethoxyphenyl) ketone (1136-86-3) → 2-bromo-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine (1438286-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 60 °C

2.1: dichloro bis(acetonitrile) palladium(II); 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 0.08 h / 20 °C / Inert atmosphere; Sealed tube

2.2: 3 h / 100 °C / Inert atmosphere; Sealed tube

With 1,1'-bis-(diphenylphosphino)ferrocene; dichloro bis(acetonitrile) palladium(II); In 1,4-dioxane; methanol;

DOI:10.1039/c3ob40263k

upstream raw materials:

4-methyl-N′-(1-(3,4,5-trimethoxyphenyl)ethylidene)benzenesulfonohydrazide

2,6-dibromo-3-methoxylpyridine

methyl (3,4,5-trimethoxyphenyl) ketone

2-bromo-6-iodo-3-methoxypyridine

Downstream raw materials:

3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridin-2-ol