N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

Base Information

Chemical Name:N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide
CAS No.:1044870-78-1
Molecular Formula:C₁₈H₁₇N₃O₃
Molecular Weight:323.351
Hs Code.:

Synonyms:N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

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Chemical Property of N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

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Technology Process of N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

There total 5 articles about N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1044872-28-7
6-amino-2-(4-hydroxy-3,5-dimethyl-phenyl)-3H-quinazolin-4-one

: 108-24-7
acetic anhydride

: 1044870-78-1
N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

Guidance literature:: 6-amino-2-(4-hydroxy-3,5-dimethyl-phenyl)-3H-quinazolin-4-one; acetic anhydride; With pyridine; at 20 ℃; for 4h;

With water; potassium carbonate; In methanol; for 4h;

With hydrogenchloride; In water;

Reference yield:

: 2233-18-3
4-hydroxy-3,5-dimethylbenzaldehyde

: 1044870-78-1
N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 155 °C

2: palladium on activated charcoal; hydrogen / N,N-dimethyl-formamide / 14 h / 20 °C

3: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 16313-65-8
2-amino-5-nitrobenzamide

: 1044870-78-1
N-(2-(4-hydroxy-3,5-dimethylphenyl)-4-oxo-3,4-dihydroquinazolin-6-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 155 °C

2: palladium on activated charcoal; hydrogen / N,N-dimethyl-formamide / 14 h / 20 °C

3: pyridine / 4 h / 20 °C / Inert atmosphere

With pyridine; palladium on activated charcoal; hydrogen; toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;