8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

Base Information

• Chemical Name: 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid
• CAS No.: 1609165-77-6
• Molecular Formula: C₁₆H₁₂F₂N₂O₃
• Molecular Weight: 320.264

Synonyms:8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

Chemical Property of 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

Chemical Property:

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Technology Process of 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid

There total 5 articles about 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethyl 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate (1609165-76-5) → 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid (1609165-77-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

methyl 2,6-difluorobenzoate (13671-00-6) → 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid (1609165-77-6)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium deuteride / tetrahydrofuran / 0 °C

2: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

3: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

With lithium aluminium deuteride; di-isopropyl azodicarboxylate; water; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; toluene;

Reference yield:

2-amino-3-benzyloxypyridine (24016-03-3) → 8-{[(2,6-difluorophenyl)(2H2)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylic acid (1609165-77-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 48 h / 100 °C / Molecular sieve

2: hydrogen; palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3: triphenylphosphine; di-isopropyl azodicarboxylate / toluene / 20 °C

4: lithium hydroxide; water / methanol; tetrahydrofuran / 20 °C

With di-isopropyl azodicarboxylate; palladium 10% on activated carbon; water; hydrogen; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; ethyl acetate; toluene;

upstream raw materials:

(2,6-difluorophenyl)(²H₂)methanol

ethyl 8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxylate

methyl 2,6-difluorobenzoate

ethyl 8-{[(2,6-difluorophenyl)(²H₂)methyl]oxy}-2-methylimidazo[1,2-a]pyridine-3-carboxylate

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