1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

Base Information

Chemical Name:1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide
CAS No.:1402888-12-3
Molecular Formula:C₂₆H₄₀N₂O₂S
Molecular Weight:444.682
Hs Code.:

Synonyms:1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

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Technology Process of 1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

There total 6 articles about 1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1402889-86-4
5-Bromo-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

: 197223-39-5
3,5-di-tert-butylphenyl boronic acid

: 1402888-12-3
1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: With potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1402889-84-2
Ethyl 1-(cyclohexylmethyl)-5-methyl-4-sulfamoyl-1H-pyrrole-2-carboxylate

: 1402888-12-3
1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / Reflux

2: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

3: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 3: Suzuki Coupling;

Reference yield:

: 3284-51-3
ethyl 5-methyl-1H-pyrrole-2-carboxylate

: 1402888-12-3
1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

With hydrogenchloride; chlorosulfonic acid; N-Bromosuccinimide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;