1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Base Information

Chemical Name:1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide
CAS No.:1402888-57-6
Molecular Formula:C₂₈H₄₄N₂O₂S
Molecular Weight:472.736
Hs Code.:

Synonyms:1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Suppliers and Price of 1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

There total 7 articles about 1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.0%

: 1402888-12-3
1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide

: 75-03-6
ethyl iodide

: 1402888-57-6
1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: 1-(Cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-2-methyl-1H-pyrrole-3-sulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -10 ℃; for 0.5h; Inert atmosphere;

ethyl iodide; In tetrahydrofuran; at 35 ℃; for 3h;

Reference yield:

: 1402889-86-4
5-Bromo-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamide

: 1402888-57-6
1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

2.2: 3 h / 35 °C

With potassium carbonate; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Suzuki Coupling;

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 1402888-57-6
1-(cyclohexylmethyl)-5-(3,5-di-tert-butylphenyl)-N-ethyl-2-methyl-1H-pyrrole-3-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 50 °C

1.2: 50 °C

2.1: chlorosulfonic acid / 36 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / ethanol; water / Reflux

4.1: N-Bromosuccinimide / tetrahydrofuran / 2 h / -78 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 120 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -10 °C / Inert atmosphere

6.2: 3 h / 35 °C

With hydrogenchloride; chlorosulfonic acid; N-Bromosuccinimide; potassium carbonate; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; 5.1: Suzuki Coupling;