{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

Base Information

Chemical Name:{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester
CAS No.:1374892-32-6
Molecular Formula:C₃₃H₃₁ClF₄N₆O₄
Molecular Weight:687.094
Hs Code.:

{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

Synonyms:{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

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Chemical Property of {(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

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Technology Process of {(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

There total 10 articles about {(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374892-28-0
((S)-1-{(S)-2-[4-(4'-amino-5'-chloro-2'-trifluoromethyl-biphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methyl-propyl)carbamic acid methyl ester

: 65352-94-5
6-fluoronicotinoyl chloride

: 1374892-32-6
{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

Reference yield:

: 1374892-28-0
((S)-1-{(S)-2-[4-(4'-amino-5'-chloro-2'-trifluoromethyl-biphenyl-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carbonyl}-2-methyl-propyl)carbamic acid methyl ester

: 1374892-32-6
{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

Guidance literature:

Reference yield:

: 1007882-04-3
(S)-2-[4-(4-bromo-phenyl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374892-32-6
{(S)-1-[(S)-2-(4-{5'-chloro-4'-[(6-fluoro-pyridine-3-carbonyl)amino]-2'-trifluoromethyl-biphenyl-4-yl}-1H-imidazol-2-yl)pyrrolidine-1-carbonyl]-2-methyl-propyl}carbamic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / methanol / 2 h / 0 °C / Inert atmosphere

2: triethylamine; HATU / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / 85 °C / Inert atmosphere

4: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 4 h / 100 °C / Inert atmosphere

5: dichloromethane / 0.08 h / 20 °C / Inert atmosphere

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;