65352-94-5Relevant articles and documents
Preparation method of 2-fluoro-5-formyl chloropyridine
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Page/Page column 4; 5, (2021/02/13)
The invention relates to a preparation method of 2-fluoro-5-formyl chloropyridine, and belongs to the technical field of organic chemistry. The method comprises the following steps: 1) taking 2-fluoro-5-methylpyridine as a raw material, and reacting in the presence of potassium permanganate or sodium permanganate to obtain 2-fluoro-5-formic acid pyridine; and 2) carrying out reflux reaction on the2-fluoro-5-formic acid pyridine and thionyl chloride or oxalyl chloride in a chlorinated solvent, after the reaction is finished, carrying out reduced pressure distillation on the solvent, adding analkane solvent, freezing, filtering to obtain a 2-fluoro-5-formyl chloropyridine solution, and carrying out reduced pressure distillation to obtain the 2-fluoro-5-formyl chloropyridine. According to the invention, the method has the advantages that the conversion rate is high, the purity of the obtained product reaches 99.0% or above, the single impurity content is smaller than 0.5%, the production cost is low, and the method is suitable for industrial production.
NOVEL NUCLEOSIDE OR NUCLEOTIDE DERIVATIVES, AND USES THEREOF
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Paragraph 0091, (2020/12/10)
The present disclosure relates to a novel nucleoside or nucleotide derivative, a racemate thereof, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating viral infection-associated diseases, containing the same as an active ingredient.
The flocculated acryloyldimethyltauric molecule ligand
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Paragraph 0574; 0717, (2016/10/08)
Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.