(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Base Information

Chemical Name:(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid
CAS No.:1335138-74-3
Molecular Formula:C₂₁H₃₃N₃O₆
Molecular Weight:423.51
Hs Code.:

Synonyms:(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Suppliers and Price of (2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

There total 11 articles about (2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 928043-35-0
1-[(chlorocarbonyl)oxy]ethyl acetate

: 1335138-62-9
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

: 1335138-74-3
(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: In dichloromethane; water; acetonitrile; at 0 ℃; for 2.5h;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335138-74-3
(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

4: CHIRALPAK IA / ethanol; hexane / Resolution of racemate

5: water; hydrogenchloride / 4 h / Reflux

6: acetonitrile; water; dichloromethane / 2.5 h / 0 °C

With piperidine; hydrogenchloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; In methanol; ethanol; hexane; dichloromethane; cyclohexane; water; acetonitrile; 2: |Knoevenagel Condensation;

Reference yield:

: 1335139-72-4
methyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335138-74-3
(2S)-5-{[(1-acetoxyethoxy)carbonyl]amino}-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 2 steps

1: water; hydrogenchloride / 4 h / Reflux

2: acetonitrile; water; dichloromethane / 2.5 h / 0 °C

With hydrogenchloride; water; In dichloromethane; water; acetonitrile;