t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

Base Information

Chemical Name:t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate
CAS No.:698373-56-7
Molecular Formula:C₂₈H₃₂FNO₂
Molecular Weight:433.566
Hs Code.:

Synonyms:t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

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Chemical Property of t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

Chemical Property:

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Technology Process of t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

There total 2 articles about t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17480-69-2
(S)-N-benzyl-1-phenylethylamine

: 14990-09-1
tert-butyl cinnamate

: 698373-56-7
t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

: t-butyl (2R,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

Guidance literature:: (S)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane;

tert-butyl cinnamate; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; hexane; at -78 ℃; for 5h;
DOI:10.1055/s-2004-817782

Reference yield:

: 265669-72-5
tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate

: 698373-56-7
t-butyl (2S,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

: t-butyl (2R,3S,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-2-fluoro-3-phenylpropanoate

Guidance literature:: tert-butyl (3R,αS)-3-[N-benzyl-N-(α-methylbenzyl)amino]-3-phenylpropanoate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

With N-fluoro-4-methyl-N-tosylbenzenesulfonamide; In tetrahydrofuran; hexane; at -78 - -35 ℃; for 4.5h; optical yield given as %de;
DOI:10.1021/jo101600c