Telatinib mesylate

Base Information

Chemical Name:Telatinib mesylate
CAS No.:332013-26-0
Molecular Formula:CH₄O₃S*C₂₀H₁₆ClN₅O₃
Molecular Weight:505.939
Hs Code.:
UNII:571LVA9UMS
NCI Thesaurus Code:C87837

Synonyms:Telatinib mesylate;Telatinib (mesylate);332013-26-0;Telatinib methanesulfonate;571LVA9UMS;332013-24-8;2-Pyridinecarboxamide, 4-(((4-((4-chlorophenyl)amino)furo(2,3-d)pyridazin-7-yl)oxy)methyl)-N-methyl-, methanesulphonate (1:1);2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-, mono(4-methylbenzenesulfonate);4-[[4-(4-chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide;methanesulfonic acid;UNII-571LVA9UMS;SCHEMBL4042879;HY-10527C;MS-29400;CS-0025251;F78022;4-(((4-((4-Chlorophenyl)amino)furo[2,3-d]pyridazin-7-yl)oxy)methyl)-N-methylpicolinamide methanesulfonate;4-((t 4-((4-Chlorophenyl))aminofuro(2,3- djpyridazin-7-yl joxy)methyl)-N-methyl-2-pyridinecarboxamide methanesulfonate

Suppliers and Price of Telatinib mesylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Telatinib mesylate

Chemical Property:

Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:505.0822822
Heavy Atom Count:34
Complexity:641

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CNC(=O)C1=NC=CC(=C1)COC2=NN=C(C3=C2OC=C3)NC4=CC=C(C=C4)Cl.CS(=O)(=O)O
Recent ClinicalTrials:Telatinib Safety and Pharmacokinetics Study in China Patients With Advanced Solid Tumors

Technology Process of Telatinib mesylate

There total 3 articles about Telatinib mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.4%

: 332012-40-5
Telatinib

: 75-75-2,98527-29-8
methanesulfonic acid

: 332013-26-0
4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate

Guidance literature:: In methanol; for 0.25h; Autoclave; Reflux; Large scale;

Reference yield:

: 332013-42-0
ethyl 2-methylaminocarbonyl-4-picolinate

: 332013-26-0
4-[({4-[(4-chlorophenyl)amino]furan[2,3-d]pyridazin-7-yl}oxy)methyl]-N-methyl-2-pyridinecarboxamide methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate / isopropyl alcohol; methanol / 8 h / 25 °C / Large scale

1.2: 1 h / 0 °C / Large scale

2.1: potassium tert-butylate / toluene; tetrahydrofuran / 24 h / 95 °C / Autoclave

3.1: methanol / 0.25 h / Autoclave; Reflux; Large scale

With sodium tetrahydroborate; potassium tert-butylate; In tetrahydrofuran; methanol; isopropyl alcohol; toluene;