2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Base Information

Chemical Name:2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide
CAS No.:1293368-10-1
Molecular Formula:C₂₁H₂₁F₂N₃O₅
Molecular Weight:433.412
Hs Code.:

Synonyms:2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

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Chemical Property of 2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

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Technology Process of 2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

There total 5 articles about 2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1293368-11-2
2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

: 1293368-10-1
2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: 2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide; With boron tribromide; In dichloromethane; at -30 - 20 ℃; Inert atmosphere;

With ammonium chloride; In dichloromethane;

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 1293368-10-1
2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4.2: 48 h / 20 °C

5.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With water; boron tribromide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 1269055-90-4
4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile

: 1293368-10-1
2-[4-(4-(4-ethyl-5-fluoro-2-hydroxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide; water / methanol / 70 °C / Reflux

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3.2: 48 h / 20 °C

4.1: boron tribromide / dichloromethane / -30 - 20 °C / Inert atmosphere

With water; boron tribromide; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;