2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Base Information

Chemical Name:2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide
CAS No.:1293368-11-2
Molecular Formula:C₂₂H₂₃F₂N₃O₅
Molecular Weight:447.439
Hs Code.:

Synonyms:2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

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Chemical Property of 2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

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Technology Process of 2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

There total 5 articles about 2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 683-57-8
bromo-acetic acid amide

: 1293368-02-1
4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazin-2-one

: 1293368-11-2
2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: 4-[4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl]piperazin-2-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.25h;

bromo-acetic acid amide; In tetrahydrofuran; mineral oil; at 20 ℃; for 48h;

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 1293368-11-2
2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydroxide / acetonitrile / 80 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 70 °C / Reflux

2.2: Cooling with ice

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

4.2: 48 h / 20 °C

With water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; mineral oil;

Reference yield:

: 1269055-90-4
4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzonitrile

: 1293368-11-2
2-[4-(4-(4-ethyl-5-fluoro-2-methoxyphenoxy)-3-fluorobenzoyl)-2-oxopiperazin-1-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 70 °C / Reflux

1.2: Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h / 20 °C

3.2: 48 h / 20 °C

With water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; mineral oil;