N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide
• CAS No.: 1421820-27-0
• Molecular Formula: C₂₇H₃₁NO₄
• Molecular Weight: 433.547

Synonyms:N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide

Chemical Property of N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide

There total 3 articles about N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-Methoxyphenylacetic acid (104-01-8) + (S)-(-)-[2-(3,4-dimethoxyphenyl)ethyl](1-phenylethyl)amine (114105-51-0) → N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide (1421820-27-0)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/adsc.201200641

Reference yield:

(3,4-Dimethoxyphenyl)acetic acid (93-40-3) → N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide (1421820-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 2 h / 20 °C

2: dmap; boron trifluoride diethyl etherate; B₂H₆*Me₂S / 3 h / 70 °C

3: dicyclohexyl-carbodiimide; dmap / dichloromethane / 2 h / 20 °C

With dmap; B₂H₆*Me₂S; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/adsc.201200641

Reference yield:

(S)-(+)-2-(3,4-dimethoxyphenyl)-N-(1-phenylethyl)acetamide (114105-64-5) → N-[2-(3,4-dimethoxyphenyl)ethyl]-N-[1-((1S)-phenyl)ethyl]-2-(4-methoxyphenyl)acetamide (1421820-27-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; boron trifluoride diethyl etherate; B₂H₆*Me₂S / 3 h / 70 °C

2: dicyclohexyl-carbodiimide; dmap / dichloromethane / 2 h / 20 °C

With dmap; B₂H₆*Me₂S; boron trifluoride diethyl etherate; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1002/adsc.201200641

upstream raw materials:

(3,4-Dimethoxyphenyl)acetic acid

(S)-(+)-2-(3,4-dimethoxyphenyl)-N-(1-phenylethyl)acetamide

4-Methoxyphenylacetic acid

(S)-(-)-[2-(3,4-dimethoxyphenyl)ethyl](1-phenylethyl)amine

Downstream raw materials:

(1R)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol

(1S)-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol

(1S)-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-2-((1S)-1-phenylethyl)-1,2,3,4-tetrahydroisoquinoline

6,7-dimethoxy-1-(4-methoxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline

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