114105-51-0Relevant articles and documents
A Base and Solvent-Free Ruthenium-Catalyzed Alkylation of Amines
Celaje, Jeff Joseph A.,Zhang, Xingyue,Zhang, Forrest,Kam, Lisa,Herron, Jessica R.,Williams, Travis J.
, p. 1136 - 1142 (2017/08/09)
A (pyridyl)phosphine-ligated ruthenium(II) catalyst is reported for the chemoselective benzylic N-alkylation of amines, via a hydrogen-borrowing mechanism. The catalyst operates under mild conditions, neat, and without a base or other additive. These conditions offer remarkable functional group compatibility for applications in organic synthesis, including reactions involving phenols and anilines, which are very difficult to achieve. Mechanistic studies suggest that, unlike other catalysts for this reaction, the redox steps are fast and reversible while imine formation is slow. We perceive that this is the origin of the selectivity realized with these reaction conditions.
Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors
Santangelo Freel, Rose M.,Ogden, Kevin K.,Strong, Katie L.,Khatri, Alpa,Chepiga, Kathryn M.,Jensen, Henrik S.,Traynelis, Stephen F.,Liotta, Dennis C.
, p. 5351 - 5381 (2013/07/26)
We describe here the synthesis and evaluation of a series of tetrahydroisoquinolines that show subunit-selective potentiation of NMDA receptors containing the GluN2C or GluN2D subunits. Bischler-Napieralski conditions were employed in the key step for the
Electrochemical synthesis and chemistry of chiral 1- cyanotetrahydroisoquinolines. An approach to the asymmetric syntheses of the alkaloid (-)-crispine A and its natural (+)-antipode
Louafi, Fadila,Moreau, Julie,Shahane, Saurabh,Golhen, Stephane,Roisnel, Thierry,Sinbandhit, Sourisak,Hurvois, Jean-Pierre
, p. 9720 - 9732 (2012/01/05)
The stereoselective convergent total syntheses of both enantiomers of the tetrahydroisoquinoline (THIQ) alkaloid crispine A are described. The THIQ precursors ( - )-6 (90:10 dr) and ( - )-11 (85:15 dr) were prepared from the alkylation - reduction sequenc