3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester

Base Information

• Chemical Name: 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester
• CAS No.: 797789-10-7
• Molecular Formula: C₃₁H₃₅Br₂NO₄
• Molecular Weight: 645.431
• Mol file: 797789-10-7.mol

Synonyms:3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester

Chemical Property of 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester

There total 3 articles about 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,4-bis-bromomethyl-benzoyl chloride (797789-09-4) + (3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester (797789-08-3) → 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester (797789-10-7)

Guidance literature:

With triethylamine; In chloroform; at 20 ℃;

DOI:10.1021/ol048433k

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester (797789-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / DMAP / CHCl₃

2: 91 percent / Et₃N / CHCl₃ / 20 °C

With dmap; triethylamine; In chloroform;

DOI:10.1021/ol048433k

Reference yield:

{4-[(3,5-dimethyl-benzylamino)-methyl]-phenyl}-methanol (252286-43-4) → 3,4-bis-bromomethyl-benzoic acid 4-{[tert-butoxycarbonyl-(3,5-dimethyl-benzyl)-amino]-methyl}-benzyl ester (797789-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / DMAP / CHCl₃

2: 91 percent / Et₃N / CHCl₃ / 20 °C

With dmap; triethylamine; In chloroform;

DOI:10.1021/ol048433k

upstream raw materials:

3,4-bis-bromomethyl-benzoyl chloride

(3,5-dimethyl-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

{4-[(3,5-dimethyl-benzylamino)-methyl]-phenyl}-methanol