1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Base Information

Chemical Name:1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
CAS No.:1374338-82-5
Molecular Formula:C₂₉H₂₃ClF₆N₄O₃
Molecular Weight:624.97
Hs Code.:

1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Synonyms:1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Chemical Property of 1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

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Technology Process of 1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

There total 9 articles about 1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6226-25-1
2,2,2-trifluoroethyl trifluoromethanesulphonate

: 1374342-01-4
ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate

: 1374338-82-5
1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: 2,2,2-trifluoroethyl trifluoromethanesulphonate; ethyl 1-{6-[4'-(azetidin-3-ylmethoxy)-4-chloro-3'-methylbiphenyl-2-yl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate trifluoroacetate; With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 0.5h;

With water; sodium hydroxide; In 1,4-dioxane; at 60 ℃; for 0.25h;

Reference yield:

: 1374342-02-5
C₃₄H₃₄ClF₃N₄O₅

: 1374338-82-5
1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.33 h

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 50 °C

2.2: 0.25 h / 60 °C

With N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1374338-82-5
1-[6-(4-chloro-3'-methyl-4'-{[1-(2,2,2-trifluoroethyl)azetidin-3-yl]methoxy}biphenyl-2-yl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / acetonitrile / 0.83 h / 60 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 3 h / 70 °C / Inert atmosphere

3.1: benzyltrimethylazanium tetrachloro-λ³-iodanuide / dichloromethane / 24 h / 20 °C

4.1: pyridine / dichloromethane / 0.42 h / 0 - 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 48 h / 80 °C / Inert atmosphere

6.1: hydrogen; palladium 10% on activated carbon / ethyl acetate; ethanol / 1.5 h / Inert atmosphere

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / 1,4-dioxane / 1.5 h / 60 °C

8.1: dichloromethane / 0.33 h

9.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0.5 h / 50 °C

9.2: 0.25 h / 60 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; sodium carbonate; benzyltrimethylazanium tetrachloro-λ³-iodanuide; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate; acetonitrile;